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dc.contributor.authorOspeck, Mark-
dc.contributor.authorEguíluz, Víctor M.-
dc.contributor.authorMagnasco, Marcelo O.-
dc.identifier.citationBiophysical Journal 80: 2597-2607 (2001)es_ES
dc.description.abstractThe membrane potential of hair cells in the low-frequency hearing organ of the bullfrog, the amphibian papilla, sinusoidally oscillates at small amplitude in the absence of acoustical input. We stimulate the cell with a series of periodic currents close to this natural frequency and observe that its current-to-voltage transfer function is compressively nonlinear, having a large gain for small stimuli and a smaller gain for larger currents. Along with the spontaneous oscillation, this implies that the cell is poised close to a dynamical instability such as a Hopf bifurcation, because distant from the instability the transfer function becomes linear. The cell’s frequency selectivity is enhanced for small stimuli. Simulations show that the cell’s membrane capacitance is effectively reduced due to a current gain provided by this dynamical instability. We propose that the Hopf resonance is widely used by transducer cells on the sensory periphery to achieve small-signal amplification.es_ES
dc.description.sponsorshipThis work was supported by National Institutes of Health Grant DC00241 to Dr. A. J. Hudspeth. During the conduct of this research M.O. was an Associate of Howard Hughes Medical Institute.es_ES
dc.publisherBiophysical Societyes_ES
dc.titleEvidence of a Hopf Bifurcation in Frog Hair Cellses_ES
dc.description.peerreviewedPeer reviewedes_ES
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