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dc.contributor.author | Lafforgue, Guillaume | - |
dc.contributor.author | Sardanyés, Josep | - |
dc.contributor.author | Elena, Santiago F. | - |
dc.date.accessioned | 2012-04-02T11:35:00Z | - |
dc.date.available | 2012-04-02T11:35:00Z | - |
dc.date.issued | 2011-03-15 | - |
dc.identifier.citation | Plos One 6/3:e17917 (2011) | es_ES |
dc.identifier.uri | http://hdl.handle.net/10261/47816 | - |
dc.description.abstract | Understanding the evolution of virulence for RNA viruses is essential for developing appropriate control strategies. Although it has been usually assumed that virulence is a consequence of within-host replication of the parasite, viral strains may be highly virulent without experiencing large accumulation as a consequence of immunopathological host responses. Using two strains of Tobacco etch potyvirus (TEV) that show a negative relationship between virulence and accumulation rate, we first explored the evolution of virulence and fitness traits during simple and mixed infections. Short-term evolution experiments initiated with each strain independently confirmed the genetic and evolutionary stability of virulence and viral load, although infectivity significantly increased for both strains. Second, competition experiments between hypo- and hypervirulent TEV strains have shown that the outcome of competition is driven by differences in replication rate. A simple mathematical model has been developed to analyze the dynamics of these two strains during coinfection. The model qualitatively reproduced the experimental results using biologically meaningful parameters. Further analyses of the model also revealed a wide parametric region in which a low-fitness but hypovirulent virus can still outcompete a high-fitness but hypervirulent one. These results provide additional support to the observation that virulence and within-host replication may not necessarily be strongly tied in plant RNA viruses. | es_ES |
dc.description.sponsorship | This work was funded by grants from the Human Frontier Science Program Organization (RGP12/2008), the Spanish Ministerio de Ciencia e Innovacio´n (BFU2009-06993) and the Generalitat Valenciana (PROMETEO2010/019). The authors also acknowledge support from the Santa Fe Institute. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Public Library of Science | es_ES |
dc.relation.isversionof | Publisher's version | - |
dc.rights | openAccess | es_ES |
dc.subject | Parasite virulence | es_ES |
dc.subject | Experimental evolution | es_ES |
dc.subject | Local adaptation | es_ES |
dc.subject | Spore production | es_ES |
dc.title | Differences in Accumulation and Virulence Determine the Outcome of Competition during Tobacco etch virus Coinfection | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1371/journal.pone.0017917 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.identifier.e-issn | 1932-6203 | - |
dc.identifier.pmid | 21423618 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | artículo | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | open | - |
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PLOS ONE 6_e17917.pdf | 383,12 kB | Adobe PDF | Visualizar/Abrir |
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