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Title

Influence of pH, temperature and the cationic porphyrin TMPyP4 on the stability of the i-motif formed by the 5′-(C3TA2)4-3′ sequence of the human telomere

AuthorsFernández, Sergio; Eritja Casadellà, Ramón ; Aviñó, Anna ; Jaumot, Joaquim ; Gargallo, Raimundo
KeywordsI-motif
Human telomere
Multivariate analysis
Loops
TMPyP4 binding
Issue Date1-Nov-2011
PublisherElsevier
CitationInternational Journal of Biological Macromolecules 49(4): 729–736 (2011)
AbstractThe influence of pH, temperature and the cationic porphyrin TMPyP4 on the conformational equilibria of the cytosine-rich strand of the human telomeric sequence 5′-(C3TA2)4-3′, as well as those of the sequence 5′-(C3TT2)4-3′, was studied. The presence of adenine bases at the loops causes the formation of two different intramolecular i-motif structures with a pH-transition midpoint around 4.6, which stability is lower than the i-motif formed by the sequence 5′-(C3TT2)4-3′. The stoichiometries of the complexes formed by these i-motif structures with TMPyP4 are also influenced by the presence of adenine at the loops.
Publisher version (URL)http://dx.doi.org/10.1016/j.ijbiomac.2011.07.004
URIhttp://hdl.handle.net/10261/47689
DOI10.1016/j.ijbiomac.2011.07.004
ISSN0141-8130
E-ISSN1879-0003
Appears in Collections:(IQAC) Artículos
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