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Título: | Influence of pH, temperature and the cationic porphyrin TMPyP4 on the stability of the i-motif formed by the 5′-(C3TA2)4-3′ sequence of the human telomere |
Autor: | Fernández, Sergio; Eritja Casadellà, Ramón CSIC ORCID ; Aviñó, Anna CSIC ORCID; Jaumot, Joaquim CSIC ORCID ; Gargallo, Raimundo | Palabras clave: | I-motif Human telomere Multivariate analysis Loops TMPyP4 binding |
Fecha de publicación: | 1-nov-2011 | Editor: | Elsevier | Citación: | International Journal of Biological Macromolecules 49(4): 729–736 (2011) | Resumen: | The influence of pH, temperature and the cationic porphyrin TMPyP4 on the conformational equilibria of the cytosine-rich strand of the human telomeric sequence 5′-(C3TA2)4-3′, as well as those of the sequence 5′-(C3TT2)4-3′, was studied. The presence of adenine bases at the loops causes the formation of two different intramolecular i-motif structures with a pH-transition midpoint around 4.6, which stability is lower than the i-motif formed by the sequence 5′-(C3TT2)4-3′. The stoichiometries of the complexes formed by these i-motif structures with TMPyP4 are also influenced by the presence of adenine at the loops. | Versión del editor: | http://dx.doi.org/10.1016/j.ijbiomac.2011.07.004 | URI: | http://hdl.handle.net/10261/47689 | DOI: | 10.1016/j.ijbiomac.2011.07.004 | ISSN: | 0141-8130 | E-ISSN: | 1879-0003 |
Aparece en las colecciones: | (IQAC) Artículos |
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influence_pH_temperature_Fernandez.pdf | 515,19 kB | Adobe PDF | Visualizar/Abrir |
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