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Title

Antibodies against β-fibrin synthetic peptides: A study of their association with the immunogenetic background and disease course of rheumatoid arthritis patients

AuthorsHaro Villar, Isabel; Gómara Elena, María José; Pérez Rodríguez, María L.; Viñas, Odette; Ercilla, Guadalupe; Gómez-Puerta, José A.; Sanmartí, Raimon
KeywordsFibrin
Peptides
Rheumatoid arthritis
Immunogenetics
Shared epitope
ELISA
Issue Date2011
PublisherElsevier
CitationEuropean Journal of Medicinal Chemistry
AbstractPreliminary studies have shown the potential application for the diagnosis of Rheumatoid Arthritis (RA) patients with a severe disease course of an epitopic domain of β-fibrin. The aim of the present work was the analysis of the presence of antibodies against several β-fibrin synthetic peptides in relation to the immunogenetic background and disease course in a clinically well-defined RA patient cohort. Our results indicated that positive patients against anti-β-fibrin synthetic peptides have a higher percentage of HLA-DRB1 shared epitope (SE) than negative patients. We also observed that the presence of SE alleles was significantly associated with a higher level of anti-[Cit376]βfib(365–383) antibodies. When analyzing the effect of different SE alleles, we found a significant positive association between carriers of QRRAA allele and [Cit376]βfib(365–383) (Odds ratio 3.77; CI95%: 1.41–10.08). These results suggest that the anti-β-fibrin status is associated with the immunogenetic background of RA patients.
Publisher version (URL)http://dx.doi.org/10.1016/j.ejmech.2011.01.024
URIhttp://hdl.handle.net/10261/47586
DOI10.1016/j.ejmech.2011.01.024
ISSN0223-5234
E-ISSN1768-3254
Appears in Collections:(IQAC) Artículos
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