Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/47586
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Antibodies against β-fibrin synthetic peptides: A study of their association with the immunogenetic background and disease course of rheumatoid arthritis patients |
Autor: | Haro Villar, Isabel CSIC ORCID ; Gómara Elena, María José CSIC ORCID; Pérez Rodríguez, María L.; Viñas, Odette; Ercilla, Guadalupe; Gómez-Puerta, José A.; Sanmartí, Raimon | Palabras clave: | Fibrin Peptides Rheumatoid arthritis Immunogenetics Shared epitope ELISA |
Fecha de publicación: | 2011 | Editor: | Elsevier | Citación: | European Journal of Medicinal Chemistry | Resumen: | Preliminary studies have shown the potential application for the diagnosis of Rheumatoid Arthritis (RA) patients with a severe disease course of an epitopic domain of β-fibrin. The aim of the present work was the analysis of the presence of antibodies against several β-fibrin synthetic peptides in relation to the immunogenetic background and disease course in a clinically well-defined RA patient cohort. Our results indicated that positive patients against anti-β-fibrin synthetic peptides have a higher percentage of HLA-DRB1 shared epitope (SE) than negative patients. We also observed that the presence of SE alleles was significantly associated with a higher level of anti-[Cit376]βfib(365–383) antibodies. When analyzing the effect of different SE alleles, we found a significant positive association between carriers of QRRAA allele and [Cit376]βfib(365–383) (Odds ratio 3.77; CI95%: 1.41–10.08). These results suggest that the anti-β-fibrin status is associated with the immunogenetic background of RA patients. | Versión del editor: | http://dx.doi.org/10.1016/j.ejmech.2011.01.024 | URI: | http://hdl.handle.net/10261/47586 | DOI: | 10.1016/j.ejmech.2011.01.024 | ISSN: | 0223-5234 | E-ISSN: | 1768-3254 |
Aparece en las colecciones: | (IQAC) Artículos |
Mostrar el registro completo
CORE Recommender
SCOPUSTM
Citations
4
checked on 24-mar-2024
WEB OF SCIENCETM
Citations
3
checked on 24-feb-2024
Page view(s)
404
checked on 27-mar-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.