Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/47202
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | The C1q domain containing proteins of the Mediterranean mussel Mytilus galloprovincialis: A widespread and diverse family of immune-related molecules |
Autor: | Gerdol, Marco; Manfrin, Chiara; Moro, Gianluca De; Figueras Huerta, Antonio CSIC ORCID ; Novoa, Beatriz CSIC ORCID; Venier, Paola; Pallavicini, Alberto | Palabras clave: | M. galloprovincialis MgC1q Immune genes Bacterial infection Expression level |
Fecha de publicación: | 2011 | Editor: | Elsevier | Citación: | Developmental and Comparative Immunology 35(6): 635-643 (2011) | Resumen: | The key component of the classical complement pathway C1q is regarded as a major connecting link between innate and acquired immunity due to the highly adaptive binding properties of its trimeric globular domain gC1q. The gC1q domain also characterizes many non-complement proteins involved in a broad range of biological processes including apoptosis, inflammation, cell adhesion and cell differentiation. In molluscs and many other invertebrates lacking of adaptive immunity, C1q domain containing (C1qDC) proteins are abundant, they most probably emerged as lectins and subsequently evolved in a specialized class of pattern recognition molecules through the expanding interaction properties of gC1q. Here we report the identification of 168 C1qDC transcript sequences of Mytilus galloprovincialis. The remarkable abundance of C1qDC transcripts in the Mediterranean mussel suggests an evolutionary strategy of gene duplication, functional diversification and selection of many specific C1qDC variants. A comprehensive transcript sequence survey in Protostomia also revealed that the C1qDC family expansion observed in mussel could have occurred in some specific taxa independently from the events leading to the establishment of a large complement of C1qDC genes in the Chordates lineage. | Descripción: | 9 páginas, 4 figuras, 3 tablas | Versión del editor: | http://dx.doi.org/10.1016/j.dci.2011.01.018 | URI: | http://hdl.handle.net/10261/47202 | DOI: | 10.1016/j.dci.2011.01.018 | ISSN: | 0145-305X |
Aparece en las colecciones: | (IIM) Artículos |
Mostrar el registro completo
CORE Recommender
SCOPUSTM
Citations
137
checked on 13-abr-2024
WEB OF SCIENCETM
Citations
126
checked on 26-feb-2024
Page view(s)
340
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.