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dc.contributor.authorGracia Villa, María de-
dc.contributor.authorJiménez-Jorquera, Cecilia-
dc.contributor.authorHaro Villar, Isabel-
dc.contributor.authorGómara Elena, María José-
dc.contributor.authorSanmartí, Raimon-
dc.contributor.authorFernández-Sánchez, César-
dc.contributor.authorMendoza Gómez, Ernest-
dc.date.accessioned2012-03-16T10:17:24Z-
dc.date.available2012-03-16T10:17:24Z-
dc.date.issued2011-
dc.identifier.citationBiosensors and Bioelectronicses_ES
dc.identifier.issn0956-5663-
dc.identifier.urihttp://hdl.handle.net/10261/47157-
dc.description.abstractThis work reports on the fabrication and performance of a simple amperometric immunosensor device to be potentially used for the detection of serum anti-citrullinated peptide antibodies (ACPAs), which are specific for rheumatoid arthritis (RA) autoimmune disease. Sera of RA patients contain antibodies to different citrullinated peptides and proteins such as fibrin or filaggrin. Herein, a chimeric fibrin–filaggrin synthetic peptide (CFFCP1) was used as a recognition element anchored to the surface of a multiwalled carbon nanotube–polystyrene (MWCNT–PS) based electrochemical transducer. The transducer fabrication process is described in detail together with its successful electrochemical performance in terms of repeatability and reproducibility of the corresponding amperometric response. The resulting immunosensor approach was initially tested in sera of rabbits previously inoculated with the synthetic peptide and eventually applied to the detection of ACPAs in human sera. A comparative study was carried out using control serum from a blood donor, which demonstrated the selectivity of the immunosensor response and its sensitivity for the detection of anti-CFFCP1 antibodies present in RA patients.es_ES
dc.description.sponsorshipPartial financial support from Consolider-Ingenio 2010 project, ref. CSD2006-00012 and project ref. CTQ2009-13969-C02-01/BQU, both from MICINN is acknowledged.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.subjectRheumatoid arthritises_ES
dc.subjectImmunosensores_ES
dc.subjectCarbon nanotube–polystyrene compositees_ES
dc.subjectAmperometryes_ES
dc.titleCarbon nanotube composite peptide-based biosensors as putative diagnostic tools for rheumatoid arthritises_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.bios.2011.06.026-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.bios.2011.06.026es_ES
dc.identifier.e-issn1873-4235-
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