Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/47120
COMPARTIR / EXPORTAR:
logo share SHARE logo core CORE BASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE

Invitar a revisión por pares abierta
Campo DC Valor Lengua/Idioma
dc.contributor.authorSols, Alberto-
dc.contributor.authorSalas, Margarita-
dc.contributor.authorViñuela, Eladio-
dc.date.accessioned2012-03-15T14:57:13Z-
dc.date.available2012-03-15T14:57:13Z-
dc.date.issued1964-
dc.identifier.citationAdvances in Enzyme Regulation, 2: 177-188 (1964)es_ES
dc.identifier.issn0065-2571-
dc.identifier.urihttp://hdl.handle.net/10261/47120-
dc.description.abstractA glucokinase qualitatively and quantitatively adequate as the first and limiting step in the synthesis of glycogen from glucose in liver has recently been identified in normal fed rats. In contrast with hexokinase, that also occurs in liver, glucokinase activity disappears in fasted and alloxandiabetic animals. The high Km, glucose-6-P-insensitive glucokinase, does not occur in muscle, nor in any of several other tissues examined. This and other indirect evidence suggest that the glucokinase is a unique enzyme of the parenchymal cells of the liver, and that the hexokinase measured in liver homogenates is present in the non-parenchymal cells. Glucokinase reappears in diabetic and fasted animals within a few hours after administration of insulin or refeeding respectively. Glucose administration alone is also effective in provoking the reappearance of glucokinase activity in previously fasted rats. Liver hexokinase remains essentially unaltered in these conditions. Inhibition of the reappearance of glucokinase by ethionine and p-fluorophenylalanine, largely counteracted by methionine and phenylalanine respectively, suggests that actual synthesis of the enzyme is involved. A similar effect of actinomycin supports this conclusion while it further suggests that formation of messenger RNA is involved. These results suggest that liver glucokinase is an inducible enzyme whose synthesis is induced directly or indirectly, by insulin. The differences in the hexosemonophosphate pathway between liver and muscle, their metabolic regulation, and the relationship with other pathways is discussed.es_ES
dc.description.sponsorshipSupported by a grant from the U.S. Public Health Service (GM-08041).es_ES
dc.language.isoenges_ES
dc.publisherPergamon Presses_ES
dc.rightsclosedAccesses_ES
dc.subjectGlucokinasees_ES
dc.subjectMessenger RNAes_ES
dc.subjectHexosemonophosphatees_ES
dc.subjectLiveres_ES
dc.titleInduced biosynthesis of liver glucokinasees_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/S0065-2571(64)80012-1-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/S0065-2571(64)80012-1es_ES
dc.contributor.funderNational Institutes of Health (US)-
dc.identifier.funderhttp://dx.doi.org/10.13039/100000002es_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.languageiso639-1en-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.grantfulltextopen-
Aparece en las colecciones: (CBM) Artículos
Ficheros en este ítem:
Fichero Descripción Tamaño Formato
Embargo.pdf21,67 kBAdobe PDFVista previa
Visualizar/Abrir
Show simple item record

CORE Recommender

SCOPUSTM   
Citations

43
checked on 19-mar-2024

WEB OF SCIENCETM
Citations

98
checked on 25-feb-2024

Page view(s)

395
checked on 17-mar-2024

Download(s)

260
checked on 17-mar-2024

Google ScholarTM

Check

Altmetric

Altmetric


NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.