English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/4699
Share/Impact:
Statistics
logo share SHARE   Add this article to your Mendeley library MendeleyBASE
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:
Title

Sharp boundaries of Dpp signalling trigger local cell death required for Drosophila leg morphogenesis

AuthorsManjón, Cristina ; Sánchez-Herrero, Ernesto ; Suzanne, Magali
KeywordsDrosophila
Decapentaplegic
Issue Date3-Dec-2006
PublisherNature Publishing Group
CitationNature Cell Biology 9, 57 - 63 (2006)
AbstractMorphogens are secreted signalling molecules that govern many developmental processes1. In the Drosophila wing disc, the transforming growth factor (TGF) homologue Decapentaplegic (Dpp) forms a smooth gradient and specifies cell fate by conferring a defined value of morphogen activity. Thus, neighbouring cells have similar amounts of Dpp protein, and if a sharp discontinuity in Dpp activity is generated between these cells, Jun kinase (JNK)-dependent apoptosis is triggered to restore graded positional information2, 3. To date, it has been assumed that this apoptotic process is only activated when normal signalling is distorted. However, we now show that a similar process occurs during normal development: rupture in Dpp activity occurs during normal segmentation of the distal legs of Drosophila. This sharp boundary of Dpp signalling, independently of the absolute level of Dpp activity, induces a JNK—reaper-dependent apoptosis required for the morphogenesis of a particular structure of the leg, the joint. Our results show that Dpp could induce a developmental programme not only in a concentration dependent manner, but also by the creation of a sharp boundary of Dpp activity. Furthermore, the same process could be used either to restore a normal pattern in response to artificial disturbance or to direct a morphogenetic process.
DescriptionArticle available at http://dx.doi.org/10.1038/ncb1518
URIhttp://hdl.handle.net/10261/4699
ISSN1465-7392
E-ISSN1476-4679
Appears in Collections:(CBM) Artículos
Files in This Item:
File Description SizeFormat 
Manjon_NatCellBiol_57.pdfMain text107,77 kBAdobe PDFThumbnail
View/Open
Manjon_NatCellBiol_Fig.1.pdfFig.12 MBAdobe PDFThumbnail
View/Open
Manjon_NatCellBiol_Fig.2.pdfFig.21,24 MBAdobe PDFThumbnail
View/Open
Manjon_NatCell Biol_Fig.3.pdfFig.31,38 MBAdobe PDFThumbnail
View/Open
Manjon_NatCell Biol_Fig.4.pdfFig.42,02 MBAdobe PDFThumbnail
View/Open
Manjon_NatCellBiol_Fig.5.JPGFig.5366,37 kBJPEGThumbnail
View/Open
Manjon_NatCellBiol_Fig.S1.pdfFig.S11,55 MBAdobe PDFThumbnail
View/Open
Manjon_NatCellBiol_fig.S2.JPGFig.S2198,47 kBJPEGThumbnail
View/Open
Manjon_NatCellBiol_Fig.S3.pdfFig.S33,22 MBAdobe PDFThumbnail
View/Open
Show full item record
Review this work
 


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.