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Campo DC | Valor | Lengua/Idioma |
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dc.contributor.author | Navas, Luis F. de | - |
dc.contributor.author | Foronda, David | - |
dc.contributor.author | Suzanne, Magali | - |
dc.contributor.author | Sánchez-Herrero, Ernesto | - |
dc.date.accessioned | 2008-05-30T11:58:45Z | - |
dc.date.available | 2008-05-30T11:58:45Z | - |
dc.date.issued | 2006-08-02 | - |
dc.identifier.citation | Mechanisms of Development, Volume 123, Issue 11, November 2006, Pages 860-867 | en_US |
dc.identifier.issn | 0925-4773 | - |
dc.identifier.uri | http://hdl.handle.net/10261/4693 | - |
dc.description.abstract | The functional replacement of one gene product by another one is a powerful method to study specificity in development and evolution. In Drosophila, the Gal4/UAS method has been used to analyze in vivo such functional substitutions. To this aim, Gal4 lines that inactivate a gene and reproduce its expression pattern are required, and they can be frequently obtained by replacing pre-existing P-lacZ lines with such characteristics. We have devised a new method to quickly identify replacements of P-lacZ lines by P-Gal4 lines, and applied it successfully to obtain Gal4 insertions in the Ultrabithorax and Abdominal-B Hox genes. We have used these lines to study the functional replacement of a Hox gene by another one. Our experiments confirm that the abdominal-A gene can replace Ultrabithorax in haltere development but that it cannot substitute for Abdominal-B in the formation of the genitalia. | en_US |
dc.description.sponsorship | This work was supported by grants from the Ministerio de Educación y Ciencia (BMC2002-00300), the Comunidad Autónoma de Madrid (No. 08.1/0031/2001.1 and GR/SAL/0147/2004) and an Institutional Grant from the Fundación Ramón Areces. | en_US |
dc.format.extent | 1868034 bytes | - |
dc.format.extent | 958179 bytes | - |
dc.format.extent | 148169 bytes | - |
dc.format.extent | 283789 bytes | - |
dc.format.extent | 1644438 bytes | - |
dc.format.extent | 408652 bytes | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | application/pdf | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | en_US |
dc.publisher | Elsevier | en_US |
dc.rights | openAccess | en_US |
dc.subject | Drosophila | en_US |
dc.subject | P-element | en_US |
dc.subject | Bithorax complex | en_US |
dc.subject | Gal4 lines | en_US |
dc.subject | Ubx | en_US |
dc.subject | Abd-B | en_US |
dc.title | A simple and efficient method to identify replacements of P-lacZ by P-Gal4 lines allows obtaining Gal4 insertions in the bithorax complex of Drosophila | en_US |
dc.type | artículo | en_US |
dc.identifier.doi | 10.1016/j.mod.2006.07.010 | - |
dc.description.peerreviewed | Peer reviewed | en_US |
dc.relation.publisherversion | http://dx.doi.org/10.1016/j.mod.2006.07.010 | - |
dc.identifier.e-issn | 1872-6356 | - |
dc.contributor.funder | Ministerio de Educación y Ciencia (España) | - |
dc.contributor.funder | Comunidad de Madrid | - |
dc.contributor.funder | Fundación Ramón Areces | - |
dc.identifier.funder | http://dx.doi.org/10.13039/100008054 | es_ES |
dc.identifier.funder | http://dx.doi.org/10.13039/100012818 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.languageiso639-1 | en | - |
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Ficheros en este ítem:
Fichero | Descripción | Tamaño | Formato | |
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DeNavas_MOD.pdf | Main text | 144,7 kB | Adobe PDF | Visualizar/Abrir |
de Navas_MOD_Fig.1.pdf | Fig.1 | 277,14 kB | Adobe PDF | Visualizar/Abrir |
de Navas_MOD_Fig.2.pdf | Fig.2 | 1,61 MB | Adobe PDF | Visualizar/Abrir |
de Navas_MOD_Fig.3.pdf | Fig.3 | 935,72 kB | Adobe PDF | Visualizar/Abrir |
de Navas_MOD_Fig.4.pdf | Fig.4 | 399,07 kB | Adobe PDF | Visualizar/Abrir |
de Navas_MOD_Fig.5.pdf | Fig.5 | 1,82 MB | Adobe PDF | Visualizar/Abrir |
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