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The molecular pathogenesis of Ewing sarcoma

AuthorsMackintosh, Carlos ; Madoz-Gúrpide, Juan ; Ordóñez, José Luis ; Osuna, Daniel; Herrero-Martín, David
Issue Date9-May-2010
PublisherLandes Bioscience
CitationCancer biology and therapy 9(9): 655-667 (2010)
AbstractEwing sarcoma family tumors (ESFT) are a group of aggressive solid bone and soft tissue malignancies of children and young adults characterized by specific chromosomal translocations that give rise to EWS-ETS aberrant transcription factors. Identification of EWS-ETS target genes and their role in tumor signaling networks together with the unravelling of the cell of origin will facilitate the translation into new treatment modalities for these neoplasms
Publisher version (URL)http://dx.doi.org/10.4161/cbt.9.9.11511
Appears in Collections:(IBMCC) Artículos
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