Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/44849COMPARTIR / EXPORTAR:
 SHARE
 CORE
BASE
|
|
| Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
| Título: | CDK-dependent phosphorylation of Mob2 is essential for hyphal development in Candida albicans |
Autor: | Gutiérrez-Escribano, Pilar; González-Novo, Alberto CSIC; Suárez, M. Belén CSIC ORCID; Vázquez de Aldana, Carlos R. CSIC ORCID CVN | Fecha de publicación: | jul-2011 | Editor: | American Society for Cell Biology | Citación: | Molecular Biology of the Cell 22(14): 2458-2469 (2011) | Resumen: | Nuclear Dbf2-related (NDR) protein kinases are essential components of regulatory pathways involved in cell morphogenesis, cell cycle control, and viability in eukaryotic cells. For their activity and function, these kinases require interaction with Mob proteins. However, little is known about how the Mob proteins are regulated. In Candida albicans, the cyclin-dependent kinase (CDK) Cdc28 and the NDR kinase Cbk1 are required for hyphal growth. Here we demonstrate that Mob2, the Cbk1 activator, undergoes a Cdc28-dependent differential phosphorylation on hyphal induction. Mutations in the four CDK consensus sites in Mob2 to Ala significantly impaired hyphal development. The mutant cells produced short hyphae with enlarged tips that displayed an illicit activation of cell separation. We also show that Cdc28 phosphorylation of Mob2 is essential for the maintenance of polarisome components at hyphal tips but not at bud tips during yeast growth. Thus we have found a novel signaling pathway by which Cdc28 controls Cbk1 through the regulatory phosphorylation of Mob2, which is crucial for normal hyphal development. | Descripción: | 12 páginas, 7 figuras.-- et al. | Versión del editor: | http://dx.doi.org/10.1091/mbc.E11-03-0205 | URI: | http://hdl.handle.net/10261/44849 | DOI: | 10.1091/mbc.E11-03-0205 | E-ISSN: | 1939-4586 |
| Aparece en las colecciones: | (IBFG) Artículos |
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| 2458.full.pdf | 3,25 MB | Adobe PDF |  Visualizar/Abrir |
CORE Recommender
PubMed Central
Citations
26
checked on 23-abr-2024
SCOPUSTM
Citations
38
checked on 15-abr-2024
WEB OF SCIENCETM
Citations
35
checked on 21-feb-2024
Page view(s)
349
checked on 22-abr-2024
Download(s)
352
checked on 22-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
Artículos relacionados:
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.