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dc.contributor.authorAgulleiro Gozalbo, Maria Josep-
dc.contributor.authorRoy, Simon-
dc.contributor.authorSánchez Martínez, Elisa-
dc.contributor.authorPuchol, Sara-
dc.contributor.authorGallo-Payet, Nicole-
dc.contributor.authorCerdá-Reverter, José Miguel-
dc.date.accessioned2012-01-23T13:42:35Z-
dc.date.available2012-01-23T13:42:35Z-
dc.date.issued2010-05-
dc.identifier.citationMolecular and Cellular Endocrinology 320(1-2): 145-152 (2010)es_ES
dc.identifier.issn0303-7207-
dc.identifier.urihttp://hdl.handle.net/10261/44603-
dc.description19 p., figuras, tablas y bibliografíaes_ES
dc.description.abstractIn this paper, we identify three different MRAPs in zebrafish, zfMRAP1, zfMRAP2a and zfMRAP2b, and demonstrate that zfMC2R is not functional in the absence of MRAP expression. ZfMRAP1 expression was restricted to adipose tissue and the anterior kidney whereas MRAP2a and MRAP2b were expressed in all the tissues tested. Quantification of surface receptor and immunofluorescence studies indicated that the receptor is unable to translocate to membrane in the absence of MRAP isoforms. MRAP1 and MRAP2b are localized in the plasma membrane in the absence of zfMC2R expression but MRAP2b is retained in perinuclear position. MRAP1 and MRAP2a displayed an equivalent translocation capacity to the membrane of zfMC2R but only zfMRAP1 expression led to intracellular cAMP increases after ACTH stimulation. ZfMRAP2b had no effect on zfMC2R activity but both zfMRAP2 isoforms enhanced the zfMRAP1-assited cAMP intracellular increase, suggesting an interaction between zfMRAP1 and zfMRAP2s when regulating zfMC2R activity.es_ES
dc.description.sponsorshipThis work was supported by grants from Ministry of Science and Innovation (MICINN) AGL2007-65744-C03-02 and CSD 2007-00002 to JM C-R, Canadian Institutes for Health Research (MOP 10998) and Canada Chairs Program to NG-P. The authors thank Lucie Chouinard and the other members of the laboratory for their technical assistance in performing cAMP assays. MJA is recipient of a “Juan de la Cierva” research contract (2009) from the Spanish Science and Innovation Ministry. SR is a recipient of a Fonds de la Recherche en Santé du Québec studentship. NGP is a recipient of a Canada Research Chair in Endocrinology of the Adrenal Gland.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsopenAccesses_ES
dc.subjectACTHes_ES
dc.subjectMRAPes_ES
dc.subjectMC2Res_ES
dc.subjectHPA-axises_ES
dc.subjectStresses_ES
dc.subjectFishes_ES
dc.titleRole of melanocortin receptor accessory proteins in the function of zebrafish melanocortin receptor type 2es_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.mce.2010.01.032-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.mce.2010.01.032es_ES
dc.identifier.e-issn1872-8057-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
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