Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/44516
COMPARTIR / EXPORTAR:
SHARE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Long-acting fentanyl analogues: Synthesis and pharmacology of N-(1-phenylpyrazolyl)-N-(1-phenylalkyl-4-piperidyl)propanamides |
Autor: | Jagerovic, Nadine CSIC ORCID ; Cano, Carolina CSIC; Elguero, José CSIC ORCID; Goya, Pilar CSIC ORCID; Callado, Luis F.; Meana, J. Javier; Girón, Rocío CSIC ORCID; Abalo, Raquel CSIC ORCID; Ruiz, David CSIC ORCID; Goicoechea, Carlos CSIC ORCID; Martín, M. Isabel CSIC | Fecha de publicación: | mar-2002 | Editor: | Pergamon Press | Citación: | Bioorganic & Medicinal Chemistry 10 : 817–827 (2002) | Resumen: | The synthesis of new fentanyl analogues in which the benzene ring of the propioanilido group has been replaced by phenylpyrazole is described. Antinociceptive activity was evaluated using the writhing and hot plate tests in mice. Two compounds, 3b and 3d, showed interesting analgesic properties, being more potent than morphine and less than fentanyl but with longer duration of action. These compounds inhibited the electrically evoked muscle contraction of guinea pig ileum and mouse vas deferens but not that of rabbit vas deferens and the effects could be reversed by antagonists (naloxone and/or CTOP), thus indicating that the compounds acted as m agonists. Finally, the binding data confirmed that the compounds had high affinity and selectivity for the m receptor. | Versión del editor: | http://pharmacist8.tripod.com/long-last-fent.pdf | URI: | http://hdl.handle.net/10261/44516 | ISSN: | 0968-0896 |
Aparece en las colecciones: | (IQM) Artículos |
Mostrar el registro completo
CORE Recommender
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.