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Title

Does exposure to testosterone significantly alter endogenous metabolism in the marine mussel Mytilus galloprovincialis?

AuthorsFernandes, Denise; Navarro, Juan Carlos ; Riva, Consuelo; Bordonali, Silvia; Porte Visa, Cinta
KeywordsTestosterone
Mytilus galloprovincialis
Testosterone acyltransferase
CYP3A
Androstenedione
5alfa-reductase
17beta-hydroxysteroid dehydrogenase
Esterification
Issue DateNov-2010
PublisherElsevier
CitationAquatic toxicology 100(4): 313-320 (2010)
AbstractMussels (Mytilus galloprovincialis) were exposed to different concentrations of testosterone (T: 20, 200 and 2000 ng/L) in a semi-static water regime (1-day dosing intervals) for up to 5 days in an attempt to see whether endogenous steroid levels and steroid metabolism were altered by exogenous exposure to testosterone. Whole tissue levels of total-testosterone (free + esterified) sharply increased in a concentrationdependent manner, from 2 ng/g in controls to 290 ng/g in organisms exposed to the highest concentration. In contrast, levels of free-testosterone were only significantly elevated at the high-exposure group (5-fold increase respect to controls). Increased activity of palmitoyl-CoA:testosterone acyltransferase (ATAT) was detected in organisms exposed to the highest concentration of testosterone, while those exposed to low and medium concentrations showed significant alterations in their polyunsaturated fatty acids profiles. The obtained results suggest that esterification of the excess of T with fatty acids might act as a homeostatic mechanism to maintain endogenous levels of free-T stable. Interestingly, a dose-dependent decrease in CYP3A-like activity was detected in T-exposed mussels together with a significant decrease in the metabolism of the androgen precursor androstenedione to dihydrotestosterone (5alfa-DHT). Overall, the work contributes to the better knowledge of androgen metabolism in mussels.
Description31 p., figuras, tablas y bibliografía
Publisher version (URL)http://dx.doi.org/10.1016/j.aquatox.2010.08.003
URIhttp://hdl.handle.net/10261/44456
DOI10.1016/j.aquatox.2010.08.003
ISSN0166-445X
E-ISSN1879-1514
Appears in Collections:(IATS) Artículos
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