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|Título :||Altitudinal and thermal gradients of hepatic Cyp1A gene expression in natural populations of Salmo trutta from high mountain lakes and their correlation with organohalogen loads|
|Autor :||Jarque, Sergio, Gallego, Eva, Bartrons, Mireia, Catalán, Jordi, Grimalt, Joan O., Piña, Benjamín|
|Palabras clave :||Gene expression|
Quantitative real-time PCR
|Fecha de publicación :||2010|
|Citación :||Environmental Pollution|
|Resumen:||The biomarker of xenobiotic exposure cytochrome p450A1 (Cyp1A) was used to analyze the biological response to chemical pollution in Salmo trutta (brown trout) from nine high mountain European lakes in Norway, Tatras, Tyrol, and central Pyrenees. Hepatic Cyp1A mRNA levels correlated both with the reciprocal of absolute annual average air temperatures of the sampled lakes and with muscle concentrations of several hydrophobic organohalogen compounds (OC), including chlorinated polychlorobiphenyls (PCB), DDE, and DDT. The correlation between Cyp1A expression and OC content was observed across the whole temperature range (between −0.7 °C and +6.2 °C), but also in the absence of any thermal gradient. We concluded that airborne pollutants accumulate in high mountain lake fish at concentrations high enough to increase Cyp1A expression, among other possible effects. As geographical distribution of semi-volatile OC is strongly influenced by air temperatures, future climate modifications will potentially enhance their physiological effects in lake ecosystems.|
|Versión del editor:||http://dx.doi.org/10.1016/j.envpol.2010.01.003|
|Appears in Collections:||(IDAEA) Artículos|
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