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Closed Access item Altitudinal and thermal gradients of hepatic Cyp1A gene expression in natural populations of Salmo trutta from high mountain lakes and their correlation with organohalogen loads

Authors:Jarque, Sergio
Gallego, Eva
Bartrons, Mireia
Catalán, Jordi
Grimalt, Joan O.
Piña, Benjamín
Keywords:Gene expression, Organochlorine compounds, Airborne pollution, Biomarkers, Quantitative real-time PCR
Issue Date:2010
Publisher:Elsevier
Citation:Environmental Pollution
Abstract:The biomarker of xenobiotic exposure cytochrome p450A1 (Cyp1A) was used to analyze the biological response to chemical pollution in Salmo trutta (brown trout) from nine high mountain European lakes in Norway, Tatras, Tyrol, and central Pyrenees. Hepatic Cyp1A mRNA levels correlated both with the reciprocal of absolute annual average air temperatures of the sampled lakes and with muscle concentrations of several hydrophobic organohalogen compounds (OC), including chlorinated polychlorobiphenyls (PCB), DDE, and DDT. The correlation between Cyp1A expression and OC content was observed across the whole temperature range (between −0.7 °C and +6.2 °C), but also in the absence of any thermal gradient. We concluded that airborne pollutants accumulate in high mountain lake fish at concentrations high enough to increase Cyp1A expression, among other possible effects. As geographical distribution of semi-volatile OC is strongly influenced by air temperatures, future climate modifications will potentially enhance their physiological effects in lake ecosystems.
Publisher version (URL):http://dx.doi.org/10.1016/j.envpol.2010.01.003
URI:http://hdl.handle.net/10261/44413
ISSN:0269-7491
1873-6424
10.1016/j.envpol.2010.01.003
Appears in Collections:(IDAEA) Artículos

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