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http://hdl.handle.net/10261/44405
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Campo DC | Valor | Lengua/Idioma |
---|---|---|
dc.contributor.author | Dardonville, Christophe | - |
dc.contributor.author | Rozas, Isabel | - |
dc.contributor.author | Goya, Pilar | - |
dc.contributor.author | Girón, Rocío | - |
dc.contributor.author | Goicoechea, Carlos | - |
dc.contributor.author | Martín, M. Isabel | - |
dc.date.accessioned | 2012-01-18T10:13:25Z | - |
dc.date.available | 2012-01-18T10:13:25Z | - |
dc.date.issued | 2003-02-03 | - |
dc.identifier.citation | Bioorganic & Medicinal Chemistry 11: 1283–1291 (2003) | es_ES |
dc.identifier.issn | 0968-0896 | - |
dc.identifier.uri | http://hdl.handle.net/10261/44405 | - |
dc.description.abstract | In the present paper, we wish to report the synthesis and antinociceptive activity of a series of new azaalkane bis(2- aminoimidazolinium) compounds from which, N,N0-di(4,5-dihydro-1H-imidazol-2-yl)-3-aza-1,6-hexanediamine 2a has shown the best analgesic properties in vivo in two different assays (i.e., acetic acid-induced writhing test and hot-plate test in mice), as well as oral bioavailability | es_ES |
dc.description.sponsorship | Financial support was provided by the Spanish DGICYT (Project SAF 97-0044-C02). C.D was a holder of a Marie Curie Research TrainingGrant for which he thanks the European Commission, Directorate General XII (Science, Research and Development). | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Pergamon Press | es_ES |
dc.rights | closedAccess | es_ES |
dc.title | Synthesis and analgesic activity of a series of new azaalkane bis-guanidinium and bis(2-aminoimidazolinium) compounds | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1016/S0968-0896(02)00637-5 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1016/S0968-0896(02)00637-5 | es_ES |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.cerifentitytype | Publications | - |
item.openairetype | artículo | - |
item.languageiso639-1 | en | - |
item.grantfulltext | none | - |
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