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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/44402
Title: Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif
Authors: Jagerovic, Nadine; Hernandez-Folgado, Laura; Alkorta, Ibon; Goya, Pilar; Serrano, Antonia; Rodriguez de Fonseca, Fernando; Dannert, M. Teresa; Alsasua, Ángela; Suardiaz, Margarita; Pascual, David; Martín, Maria Isabel
Keywords: Cannabinoid Antagonist
Issue Date: 20-May-2004
Publisher: American Chemical Society
Citation: Journal of Medicinal Chemistry 47 (11) : 2939–2942 (2004)
Abstract: A new series of 1,2,4-triazoles have been prepared and the evaluation of their cannabinoid properties have been carried out. Compound 8 showed cannabinoid silent antagonist activity in mouse vas deferens and guinea pig ileum preparations and in vivo assays (cannabinoid tetrad) in mouse. It did not have intrinsic activity in these bioassays, and therefore, it did not behave as a partial agonist or an inverse agonist
Publisher version (URL): http://dx.doi.org/10.1021/jm031099y
URI: http://hdl.handle.net/10261/44402
DOI: 10.1021/jm031099y
ISSN: 0022-2623
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