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Closed Access item Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif

Authors:Jagerovic, Nadine
Hernandez-Folgado, Laura
Alkorta, Ibon
Goya Laza, Pilar
Serrano, Antonia
Rodriguez de Fonseca, Fernando
Dannert, M. Teresa
Alsasua, Ángela
Suardiaz, Margarita
Pascual, David
Martín, Maria Isabel
Keywords:Cannabinoid Antagonist
Issue Date:20-May-2004
Publisher:American Chemical Society
Citation:Journal of Medicinal Chemistry 47 (11) : 2939–2942 (2004)
Abstract:A new series of 1,2,4-triazoles have been prepared and the evaluation of their cannabinoid properties have been carried out. Compound 8 showed cannabinoid silent antagonist activity in mouse vas deferens and guinea pig ileum preparations and in vivo assays (cannabinoid tetrad) in mouse. It did not have intrinsic activity in these bioassays, and therefore, it did not behave as a partial agonist or an inverse agonist
Publisher version (URL):http://dx.doi.org/10.1021/jm031099y
Appears in Collections:(IQM) Artículos

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