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Título : Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif
Autor : Jagerovic, Nadine, Hernandez-Folgado, Laura, Alkorta, Ibon, Goya, Pilar, Serrano, Antonia, Rodriguez de Fonseca, Fernando, Dannert, M. Teresa, Alsasua, Ángela, Suardiaz, Margarita, Pascual, David, Martín, Maria Isabel
Palabras clave : Cannabinoid Antagonist
Fecha de publicación : 20-May-2004
Editor: American Chemical Society
Resumen: A new series of 1,2,4-triazoles have been prepared and the evaluation of their cannabinoid properties have been carried out. Compound 8 showed cannabinoid silent antagonist activity in mouse vas deferens and guinea pig ileum preparations and in vivo assays (cannabinoid tetrad) in mouse. It did not have intrinsic activity in these bioassays, and therefore, it did not behave as a partial agonist or an inverse agonist
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ISSN: 0022-2623
Citación : Journal of Medicinal Chemistry 47 (11) : 2939–2942 (2004)
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