Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/44402
Título : Discovery of 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole, a novel in vivo cannabinoid antagonist containing a 1,2,4-triazole motif
Autor : Jagerovic, Nadine, Hernandez-Folgado, Laura, Alkorta, Ibon, Goya, Pilar, Serrano, Antonia, Rodriguez de Fonseca, Fernando, Dannert, M. Teresa, Alsasua, Ángela, Suardiaz, Margarita, Pascual, David, Martín, Maria Isabel
Palabras clave : Cannabinoid Antagonist
Fecha de publicación : 20-May-2004
Editor: American Chemical Society
Citación : Journal of Medicinal Chemistry 47 (11) : 2939–2942 (2004)
Resumen: A new series of 1,2,4-triazoles have been prepared and the evaluation of their cannabinoid properties have been carried out. Compound 8 showed cannabinoid silent antagonist activity in mouse vas deferens and guinea pig ileum preparations and in vivo assays (cannabinoid tetrad) in mouse. It did not have intrinsic activity in these bioassays, and therefore, it did not behave as a partial agonist or an inverse agonist
Versión del editor: http://dx.doi.org/10.1021/jm031099y
URI : http://hdl.handle.net/10261/44402
ISSN: 0022-2623
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