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Novel sulfamide analogs of oleoylethanolamide showing in vivo satiety inducing actions and PPAR alpha activation

AuthorsCano, Carolina ; Pavón, Javier; Serrano, Antonia; Goya, Pilar ; Páez, Juan A. ; Rodriguez de Fonseca, Fernando; Macías-González, Manuel
Issue Date2007
PublisherAmerican Chemical Society
CitationJournal of Medicinal Chemistry 50 : 389-393 (2007)
AbstractLong chain saturated and unsaturated alkyl sulfamide and propyl sulfamide derivatives, analogs of oleoylethanolamide, have been synthesized and evaluated in ViVo and in Vitro as peroxisome proliferator activated receptor alpha (PPARR) activators. Additionally, the anorexic effects of the new compounds have been studied in ViVo in food-deprived rats. Among the active compounds N-octadecyl-N¢-propylsulfamide (7) has been identified as a potent hypolipidemic compound, a potent feeding suppressant, and a concentrationdependent activator of PPARR.
Publisher version (URL)http://dx.doi.org/10.1021/jm0601102
Appears in Collections:(IQM) Artículos
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