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Closed Access item Altitudinal gradients of hepatic Cyp1A gene expression in mountain trout correlate with geographic and individual organohalogen distribution.
Grimalt, Joan O.
|Keywords:||Gene expression, Organochlorine compounds, Airborne pollution, Biomarkers, Quantitative real-time PCR|
|Citation:||Environmental Pollution 158 : 1392-1398 (2010)|
|Abstract:||The biomarker of xenobiotic exposure cytochrome p450A1 (Cyp1A) was used to analyze the biological
response to chemical pollution in Salmo trutta (brown trout) from nine high mountain European lakes in
Norway, Tatras, Tyrol, and central Pyrenees. Hepatic Cyp1A mRNA levels correlated both with the
reciprocal of absolute annual average air temperatures of the sampled lakes and with muscle concentrations
of several hydrophobic organohalogen compounds (OC), including chlorinated polychlorobiphenyls
(PCB), DDE, and DDT. The correlation between Cyp1A expression and OC content was
observed across the whole temperature range (between 0.7 C and þ6.2 C), but also in the absence of
any thermal gradient. We concluded that airborne pollutants accumulate in high mountain lake fish at
concentrations high enough to increase Cyp1A expression, among other possible effects. As geographical
distribution of semi-volatile OC is strongly influenced by air temperatures, future climate modifications
will potentially enhance their physiological effects in lake ecosystems.|
|Description:||7 páginas, 3 figuras, 3 tablas.|
|Publisher version (URL):||http://dx.doi.org/10.1016/j.envpol.2010.01.003|
|Appears in Collections:||(CEAB) Artículos|
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