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Title

Association Analysis of Urotensin II Gene (UTS2) and Flanking Regions with Biochemical Parameters Related to Insulin Resistance

AuthorsSáez, María E.; Smani, Tarik; Ramírez Lorca, Reposo; Díaz Carrasco, Ignacio; Serrano, Manuel; Ruiz, Agustín; Ordóñez Fernández, Antonio
Issue Date29-Apr-2011
PublisherPublic Library of Science
CitationPLoS ONE 6(4): e19327 (2011)
AbstractBackground Urotensin II (UII) is a potent vasoconstrictor peptide, which signals through a G-protein coupled receptor (GPCR) known as GPR14 or urotensin receptor (UTR). UII exerts a broad spectrum of actions in several systems such as vascular cell, heart muscle or pancreas, where it inhibits insulin release. Objective Given the reported role of UII in insulin secretion, we have performed a genetic association analysis of the UTS2 gene and flanking regions with biochemical parameters related to insulin resistance (fasting glucose, glucose 2 hours after a glucose overload, fasting insulin and insulin resistance estimated as HOMA). Results and Conclusions We have identified several polymorphisms associated with the analysed clinical traits, not only at the UTS2 gene, but also in thePER3 gene, located upstream from UTS2. Our results are compatible with a role for UII in glucose homeostasis and diabetes although we cannot rule out the possibility that PER3 gene may underlie the reported associations.
Publisher version (URL)http://dx.doi.org/10.1371/journal.pone.0019327
URIhttp://hdl.handle.net/10261/43677
DOI10.1371/journal.pone.0019327
ISSN1932-6203
Appears in Collections:(IBIS) Artículos
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