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Por favor, use este identificador para citar o enlazar a este item: http://hdl.handle.net/10261/43658
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dc.contributor.authorSoin, Thomas-
dc.contributor.authorMartín Casacuberta, David A.-
dc.contributor.authorSwevers, Luc-
dc.date.accessioned2011-12-22T12:22:43Z-
dc.date.available2011-12-22T12:22:43Z-
dc.date.issued2010-05-
dc.identifier.citationPest Management Science 66(5): 526-535 (2010)es_ES
dc.identifier.issn1526-498X-
dc.identifier.urihttp://hdl.handle.net/10261/43658-
dc.description10 páginas, 4 figuras, 4 tablas.-- Soin, Thomas et al.es_ES
dc.description.abstract[BACKGROUND] Dibenzoylhydrazine analogues have been developed successfully as a new group of insect growth regulators, called ecdysone agonists or moulting accelerating compounds. A notable feature is their high activity against lepidopteran insects, raising the question as to whether species-specific analogues can be isolated. In this study, the specificity of ecdysone agonists was addressed through a comparative analysis in two important lepidopterans, the silkworm Bombyx mori L. and the cotton leafworm Spodoptera littoralis (Boisd.).es_ES
dc.description.abstract[RESULTS] When collections of non-steroidal ecdysone agonists containing different mother structures (dibenzoylhydrazine, acylaminoketone, tetrahydroquinoline) were tested, in vitro reporter assays showed minor differences using cell lines derived from both species. However, when compounds with high ecdysone agonist activity were examined in toxicity assays, larvicidal activity differed considerably. Of note was the identification of three dibenzoylhydrazine analogues with > 100-fold higher activity against Bombyx than against Spodoptera larvae.-
dc.description.abstract[CONCLUSION] The present study demonstrated that species-specific ecdysone-agonist-based insecticides can be developed, but their species specificity is not based on differences in the activation of the ecdysone receptor but rather on unidentified in vivo parameters such as permeability of the cuticle, uptake/excretion by the gut or metabolic detoxification.-
dc.description.sponsorshipThis research was supported by a PhD grant (No. 43628) from the Institute for the Promotion of Innovation by Science and Technology in Flanders (IWT, Belgium) to T Soin, and support by the Fund for Scientific Research (FWO-Vlaanderen, Belgium) to G. Smagghe. Research on ecdysone agonists at the Insect Molecular Genetics and Biotechnology Group at the Institute of Biology, National Centre for Scientific Research ‘Demokritos’, was supported by two bilateral scientific and technological cooperation grants (Greece–Japan and Greece–Spain) from the General Secretariat for Research and Technology, Ministry of Development, in Greece. The study was also supported by the twenty-first century COE programme for Innovative Food and Environmental Studies Pioneered by Entomomimetic Sciences, from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and by the Spanish Ministry of Education and Science for project BFU2006-13212 and a bilateral scientific cooperation grant (Spain–Greece).es_ES
dc.language.isoenges_ES
dc.publisherWiley-Blackwelles_ES
dc.rightsclosedAccesses_ES
dc.subjectEcdysone agonistes_ES
dc.subjectMoulting accelerating compoundes_ES
dc.subjectBombyx mories_ES
dc.subjectSpodoptera littoralises_ES
dc.subjectInsect growth regulatores_ES
dc.subjectLepidopteran cell linees_ES
dc.titleAssessment of species specificity of moulting accelerating compounds in Lepidoptera: comparison of activity between Bombyx mori and Spodoptera littoralis by in vitro reporter and in vivo toxicity assayses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1002/ps.1903-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1002/ps.1903es_ES
dc.identifier.e-issn1526-4998-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
item.openairetypeartículo-
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