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Assessment of species specificity of moulting accelerating compounds in Lepidoptera: comparison of activity between Bombyx mori and Spodoptera littoralis by in vitro reporter and in vivo toxicity assays

AuthorsSoin, Thomas; Martín Casacuberta, David A. ; Swevers, Luc
KeywordsEcdysone agonist
Moulting accelerating compound
Bombyx mori
Spodoptera littoralis
Insect growth regulator
Lepidopteran cell line
Issue DateMay-2010
CitationPest Management Science 66(5): 526-535 (2010)
Abstract[BACKGROUND] Dibenzoylhydrazine analogues have been developed successfully as a new group of insect growth regulators, called ecdysone agonists or moulting accelerating compounds. A notable feature is their high activity against lepidopteran insects, raising the question as to whether species-specific analogues can be isolated. In this study, the specificity of ecdysone agonists was addressed through a comparative analysis in two important lepidopterans, the silkworm Bombyx mori L. and the cotton leafworm Spodoptera littoralis (Boisd.).
[RESULTS] When collections of non-steroidal ecdysone agonists containing different mother structures (dibenzoylhydrazine, acylaminoketone, tetrahydroquinoline) were tested, in vitro reporter assays showed minor differences using cell lines derived from both species. However, when compounds with high ecdysone agonist activity were examined in toxicity assays, larvicidal activity differed considerably. Of note was the identification of three dibenzoylhydrazine analogues with > 100-fold higher activity against Bombyx than against Spodoptera larvae.
[CONCLUSION] The present study demonstrated that species-specific ecdysone-agonist-based insecticides can be developed, but their species specificity is not based on differences in the activation of the ecdysone receptor but rather on unidentified in vivo parameters such as permeability of the cuticle, uptake/excretion by the gut or metabolic detoxification.
Description10 páginas, 4 figuras, 4 tablas.-- Soin, Thomas et al.
Publisher version (URL)http://dx.doi.org/10.1002/ps.1903
Appears in Collections:(IBE) Artículos
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