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Título: | Multiplex single-nucleotide polymorphism typing of the human Y chromosome using TaqMan probes |
Otros títulos: | Multiplex screening of the human Y chromosome using TaqMan probes | Autor: | Martínez-Cruz, Begoña CSIC ORCID; Ziegle, Janet; Sanz, Paula CSIC; Sotelo, Graciela; Anglada, Roger; Plaza, Stéphanie; Comas, David CSIC ORCID | Fecha de publicación: | 31-may-2011 | Editor: | BioMed Central | Citación: | Investigative Genetics 2: 13 (2011) | Resumen: | [Background] The analysis of human Y-chromosome variation in the context of population genetics and forensics requires the genotyping of dozens to hundreds of selected single-nucleotide polymorphisms (SNPs). In the present study, we developed a 121-plex (121 SNPs in a single array) TaqMan array capable of distinguishing most haplogroups and subhaplogroups on the Y-chromosome human phylogeny in Europe. [Results] We present data from 264 samples from several European areas and ethnic groups. The array developed in this study shows >99% accuracy of assignation to the Y human phylogeny (with an average call rate of genotypes >96%). [Conclusions] We have created and evaluated a robust and accurate Y-chromosome multiplex which minimises the possible errors due to mixup when typing the same sample in several independent reactions. |
Descripción: | Grupo de trabajo: The Genographic Consortium. | Versión del editor: | http://dx.doi.org/10.1186/2041-2223-2-13 | URI: | http://hdl.handle.net/10261/43344 | DOI: | 10.1186/2041-2223-2-13 | ISSN: | 2041-2223 | E-ISSN: | 2041-2223 |
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