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dc.contributor.authorMuñoz, Albertoes_ES
dc.contributor.authorLópez García, Belénes_ES
dc.contributor.authorPérez-Payá, Enriquees_ES
dc.contributor.authorMarcos López, José Franciscoes_ES
dc.date.accessioned2008-05-19T07:49:40Z-
dc.date.available2008-05-19T07:49:40Z-
dc.date.issued2007-03-
dc.identifier.citationBiochem Biophys Res Commun 354 (1): 172-177es_ES
dc.identifier.urihttp://hdl.handle.net/10261/4324-
dc.descriptionThe definitive version is available at http://www.sciencedirect.com/science/journal/0006291Xen_US
dc.description.abstractShort antimicrobial peptides represent an alternative to fight pathogen infections. PAF26 is a hexapeptide identified previously by a combinatorial approach against the fungus Penicillium digitatum and shows antimicrobial properties towards certain phytopathogenic fungi. In this work, PAF26 was used as lead compound and its properties were compared with two series of derivatives, obtained by either systematic alanine substitution or N-terminal amino acid addition. The alanine scan approach underlined the optimized sequence of PAF26 in terms of potency and permeation capability, and also the higher contribution of the cationic residues to these properties. The N-terminal addition of amino acids resulted in new heptapeptides with variations in their antimicrobial characteristics, and very low cytolysis to human red blood cells. Positive (Arg or Lys) and aromatic (Phe or Trp) residue addition increased broad spectrum activity of PAF26. Noteworthy, addition of selected residues had specific effects on the properties of derivatives of PAF26.en_US
dc.description.sponsorshipWork was supported by grants BIO2003-00927 and BIO2006-09523 from the Spanish Ministry of Education and Science (MEC). B.L.-G. acknowledges the post doctoral program “Juan de la Cierva” of the Spanish MEC.en_US
dc.format.extent863841 bytes-
dc.format.mimetypeapplication/pdf-
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsopenAccessen_US
dc.subjectTryptophan-rich cationic antimicrobial peptideen_US
dc.subjectAMPen_US
dc.subjectAntifungal peptideen_US
dc.subjectPhytopathogenic fungien_US
dc.subjectP. digitatumen_US
dc.subjectB. cinereaen_US
dc.subjectM. griseaen_US
dc.subjectF. oxysporumen_US
dc.titleAntimicrobial properties of derivatives of the cationic tryptophan-rich hexapeptide PAF26es_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.bbrc.2006.12.173-
dc.description.peerreviewedPeer revieweden_US
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.bbrc.2006.12.173-
dc.relation.csices_ES
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
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