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Título: | Effect of lead on ALA-D activity, metallothionein levels, and lipid peroxidation in blood, kidney, and liver of the toadfish Halobatrachus didactylus |
Autor: | Campana, Olivia CSIC ORCID; Sarasquete, Carmen CSIC ORCID ; Blasco, Julián CSIC ORCID | Palabras clave: | Lead δ-aminolevulinic acid dehydratase Metallithionein Lipid peroxidation products Blood Liver Kidney Halobatrachus didactylus |
Fecha de publicación: | 25-feb-2003 | Editor: | Elsevier | Citación: | Ecotoxicology and Environmental Safety 55(1): 116-125 (2003) | Resumen: | The effects of lead (Pb) on ALA-D activity, metallothionein (MT) levels, and lipid peroxidation in liver, kidney, and blood of the toadfish Halobatrachus didactylus were investigated. A time-course experiment was performed with sampling on days 0, 2, 5, and 7 following intraperitoneal Pb injection. This indicated a rank order for lead concentration of kidney>liver>blood in fish exposed to Pb. No significant variation of ALA-D activity was observed in liver and kidney while in blood, a slight decrease of ALA-D activity was found but this was not attributed to acute metal stress. Hepatic and renal MT levels were both affected in different ways by metal uptake. The progressive decrease of MDA concentration in the liver and the lack of a clear induction in kidney suggested the hypothesis that Pb is not a good inductor of lipid peroxidation. The histological and histochemical results demonstrated degenerative effects of lead accumulation on the tissues and the activation of lysosomal responses to induced stress. | Descripción: | 10 páginas, 7 figuras, 1 tabla. | Versión del editor: | http://dx.doi.org/10.1016/S0147-6513(02)00093-3 | URI: | http://hdl.handle.net/10261/43219 | DOI: | 10.1016/S0147-6513(02)00093-3 | ISSN: | 0147-6513 | E-ISSN: | 1090-2414 |
Aparece en las colecciones: | (ICMAN) Artículos |
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