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Classical and novel roles of p53 and prospects for anticancer therapy

AutorFuster, José J. ; Sanz-González, Silvia M. ; Moll, Ute M.; Andrés, Vicente
Palabras clavep53
MDM2
Cancer
Aging
Mitochondria
Genetically-engineered mice
Anticancer therapy
Fecha de publicaciónmay-2007
EditorElsevier
CitaciónTrends Mol Med 13 (5): 192-199
ResumenThe tumor suppressor p53 is a transcription factor that is frequently inactivated in human tumors. Therefore,restoring its function has been considered an attractive approach to restrain cancer. Typically, p53-dependent growth arrest, senescence and apoptosis of tumor cells have been attributed to transcriptional activity of nuclear p53. Notably, wild-type p53 gain-of-function enhances cancer resistance in the mouse, but it also accelerates aging in some models, possibly due to altered p53 activity. Therefore, the emerging evidence of mitochondrial transcription-independent activities of p53 has raised high expectations. Here, we review new developments in transcription-dependent and transcription-independent p53 functions, recent advances in targeting p53 for cancer treatment and the pitfalls of moving from the laboratory research to the clinical setting.
DescripciónThe definitive version is available at http://www.sciencedirect.com/science/journal/14714914
Versión del editorhttp://dx.doi.org/10.1016/j.molmed.2007.03.002
URIhttp://hdl.handle.net/10261/4227
DOI10.1016/j.molmed.2007.03.002
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