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http://hdl.handle.net/10261/42259
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dc.contributor.author | Moreno-Bueno, Gema | - |
dc.contributor.author | Salvador, Fernando | - |
dc.contributor.author | Martín, Alberto | - |
dc.contributor.author | Floristán, Alfredo | - |
dc.contributor.author | Cuevas, Eva P. | - |
dc.contributor.author | Santos, Vanesa | - |
dc.contributor.author | Montes, Amalia | - |
dc.contributor.author | Morales, Saleta | - |
dc.contributor.author | Castilla, María Ángeles | - |
dc.contributor.author | García del Portillo, Francisco | - |
dc.contributor.author | Peinado, Héctor | - |
dc.contributor.author | Palacios Calvo, José | - |
dc.contributor.author | Cano, Amparo | - |
dc.date.accessioned | 2011-11-08T12:53:06Z | - |
dc.date.available | 2011-11-08T12:53:06Z | - |
dc.date.issued | 2011-09 | - |
dc.identifier.citation | EMBO Molecular Medicine 3(9): 528-544 (2011) | es_ES |
dc.identifier.issn | 1757-4676 | - |
dc.identifier.uri | http://hdl.handle.net/10261/42259 | - |
dc.description.abstract | Basal-like breast carcinoma is characterized by the expression of basal/myoepithelial markers, undifferentiated phenotype, highly aggressive behaviour and frequent triple negative status (ESR−, PR−, Her2neu−). We have previously shown that epithelial–mesenchymal transition (EMT) occurs in basal-like breast tumours and identified Lysyl-oxidase-like 2 (LOXL2) as an EMT player and poor prognosis marker in squamous cell carcinomas. We now show that LOXL2 mRNA is overexpressed in basal-like human breast carcinomas. Breast carcinoma cell lines with basal-like phenotype show a specific cytoplasmic/perinuclear LOXL2 expression, and this subcellular distribution is significantly associated with distant metastatic incidence in basal-like breast carcinomas. LOXL2 silencing in basal-like carcinoma cells induces a mesenchymal-epithelial transition (MET) associated with a decrease of tumourigenicity and suppression of metastatic potential. Mechanistic studies indicate that LOXL2 maintains the mesenchymal phenotype of basal-like carcinoma cells by a novel mechanism involving transcriptional downregulation of Lgl2 and claudin1 and disorganization of cell polarity and tight junction complexes. Therefore, intracellular LOXL2 is a new candidate marker of basal-like carcinomas and a target to block metastatic dissemination of this aggressive breast tumour subtype. | es_ES |
dc.language.iso | eng | es_ES |
dc.publisher | Wiley-Blackwell | es_ES |
dc.publisher | European Molecular Biology Organization | es_ES |
dc.rights | closedAccess | es_ES |
dc.subject | Basal-like carcinomas | es_ES |
dc.subject | Breast cancer | es_ES |
dc.subject | EMT | es_ES |
dc.subject | LOXL2 | es_ES |
dc.subject | Metastasis | es_ES |
dc.title | Lysyl oxidase-like 2 (LOXL2), a new regulator of cell polarity required for metastatic dissemination of basal-like breast carcinomas | es_ES |
dc.type | artículo | es_ES |
dc.identifier.doi | 10.1002/emmm.201100156 | - |
dc.description.peerreviewed | Peer reviewed | es_ES |
dc.relation.publisherversion | http://dx.doi.org/10.1002/emmm.201100156 | es_ES |
dc.identifier.e-issn | 1757-4684 | - |
dc.identifier.pmid | 21732535 | - |
dc.type.coar | http://purl.org/coar/resource_type/c_6501 | es_ES |
item.openairetype | artículo | - |
item.grantfulltext | none | - |
item.cerifentitytype | Publications | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | No Fulltext | - |
item.languageiso639-1 | en | - |
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