DSpace

Digital.CSIC > Biología y Biomedicina > Centro de Biología Molecular Severo Ochoa (CBM) > (CBM) Artículos >

Share

EndNote

Impact

Links

Closed Access item Conserved cross-interactions in Drosophila and Xenopus between Ras/MAPK signaling and the dual-specificity phosphatase MKP3

Authors:Ruiz Gómez, Ana
López-Varea, Ana
Molnar, Cristina
Calle-Mustienes, Elisa de la
Ruiz-Gómez, Mar
Gómez-Skarmeta, José Luis
Celis, José F. de
Keywords:Cell signaling, MAPK, Vein formation, Negative feedback, Neural development, Drosophila, Xenopus
Issue Date:9-Feb-2005
Publisher:Wiley-Liss Inc.
Citation:Developmental Dynamics 232(3): 695-708 (2005)
Abstract:The extracellular signal-regulated kinase (ERK) is a key transducer of the epidermal growth factor receptor (EGFR) and fibroblast growth factor receptor (FGFR) signaling pathways, and its function is required in multiple processes during animal development. The activity of ERK depends on the phosphorylation state of conserved threonine and tyrosine residues, and this state is regulated by different kinases and phosphatases. A family of phosphatases with specificity toward both threonine and tyrosine residues in ERK (dual-specificity phosphatases) play a conserved role in its dephosphorylation and consequent inactivation. Here, we characterize the function of the dual-specificity phosphatase MKP3 in Drosophila EGFR and Xenopus FGFR signaling. The function of MKP3 is required during Drosophila wing vein formation and Xenopus anteroposterior neural patterning. We find that the expression of the MKP3 gene is localized in places of high EGFR and FGFR signaling. Furthermore, this restricted expression depends on ERK function both in Drosophila and Xenopus, suggesting that MKP3 constitutes a conserved negative feedback loop on the activity of the Ras/ERK signaling pathway.
Description:9 páginas, 7 figuras.
Publisher version (URL):http://dx.doi.org/10.1002/dvdy.20227
URI:http://hdl.handle.net/10261/41859
ISSN:1058-8388
E-ISSNmetadata.dc.identifier.doi = DOI:1097-0177
???metadata.dc.identifier.doi???:10.1002/dvdy.20227
Appears in Collections:(CBM) Artículos

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.