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Antioxidanst in differentiation of leukemic cells

AuthorsLópez-Lluch, Guillermo ; Siendones, Emilio ; Moreno Fernández-Ayala, Daniel José; Navas, Plácido
Issue Date2007
PublisherNova Science Publishers
CitationNew cell differentiation research topics: 79-116 (2007)
AbstractThe therapy of leukaemia based on the use of compounds able to reinitiate the differentiation program has been extensively studied. The use of calcitriol (1,25D3) or trans-retinoic acid (ATRA) in myeloid or monocytic leukemic cell differentiation has been also clinically taken into consideration. Both are natural compounds accepted at relatively high doses by the organism, however, several other secondary effects take place because their other respective main functions different than regulating the differentiation program in cancerous cells. To avoid the secondary effects due to overloading of both, ATRA or 1,25D3, therapies based on the co-administration of other natural compounds such as vitamin C, vitamin E, polyphenols, caretonoids or other antioxidants acting as anti-cancer active compounds have been taking into consideration. In several cases, these natural compounds do not affect by themselves the differentiation program in leukemic cells but they are able to enhance the effect of the differentiation-active compounds such as ATRA or 1,25D3. The present chapter reviews the effect of the combination of these natural antioxidant compounds on the treatment of leukemic cells and will try to define the probable common mechanism of action for this plethora of substances.
Description38 páginas, 3 figuras, 1 tabla. Editor: Hitoshi Saitama.
Appears in Collections:(CABD) Libros y partes de libros
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