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Open Access item Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span

Authors:Pearson, Kevin J.
Baur, Joseph A.
Lewis, Kaitlyn N.
Peshkin, Leonid
Price, Nathan L.
Labinskyy, Nazar
Swindell, William R.
Kamara, Davida
Minor, Robin K.
Pérez, Evelin
Jamieson, Hamish A.
Zhang, Yongqing
Dunn, Stephen R.
Sharma, Kumar
Pleshko, Nancy
Woollett, Laura A.
Csiszar, Anna
Ikeno, Yuji
Couteur, David le
Elliott, Peter J.
Becker, Kevin G.
Navas, Plácido
Ingram, Donald K.
Wolf, Norman S.
Ungvari, Zoltan
Sinclair, David A.
Cabo, Rafael de
Keywords:Antioxidants, Stilbenes, Resveratrol, Gene expression regulation, Aging, Apoptosis, Cardiovascular system, Osteoporosis
Issue Date:3-Jul-2008
Citation:Cell Metabolism 8(2): 157-168 (2008)
Abstract:A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others have shown that resveratrol mimics effects of DR in lower organisms. In mice, we find that resveratrol induces gene expression patterns in multiple tissues that parallel those induced by DR and every-other-day feeding. Moreover, resveratrol-fed elderly mice show a marked reduction in signs of aging, including reduced albuminuria, decreased inflammation, and apoptosis in the vascular endothelium, increased aortic elasticity, greater motor coordination, reduced cataract formation, and preserved bone mineral density. However, mice fed a standard diet did not live longer when treated with resveratrol beginning at 12 months of age. Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.
Description:22 páginas, 4 figuras.
Publisher version (URL):http://dx.doi.org/10.1016/j.cmet.2008.06.011
E-ISSNmetadata.dc.identifier.doi = DOI:1932-7420
Appears in Collections:(CABD) Artículos

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