Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/41582
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Title: Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life Span
Authors: Pearson, Kevin J., Baur, Joseph A., Lewis, Kaitlyn N., Peshkin, Leonid, Price, Nathan L., Labinskyy, Nazar, Swindell, William R., Kamara, Davida, Minor, Robin K., Pérez, Evelin, Jamieson, Hamish A., Zhang, Yongqing, Dunn, Stephen R., Sharma, Kumar, Pleshko, Nancy, Woollett, Laura A., Csiszar, Anna, Ikeno, Yuji, Couteur, David le, Elliott, Peter J., Becker, Kevin G., Navas, Plácido, Ingram, Donald K., Wolf, Norman S., Ungvari, Zoltan, Sinclair, David A., Cabo, Rafael de
Keywords: Antioxidants
Stilbenes
Resveratrol
Gene expression regulation
Aging
Apoptosis
Cardiovascular system
Osteoporosis
Issue Date: 3-Jul-2008
Publisher: Elsevier
Abstract: A small molecule that safely mimics the ability of dietary restriction (DR) to delay age-related diseases in laboratory animals is greatly sought after. We and others have shown that resveratrol mimics effects of DR in lower organisms. In mice, we find that resveratrol induces gene expression patterns in multiple tissues that parallel those induced by DR and every-other-day feeding. Moreover, resveratrol-fed elderly mice show a marked reduction in signs of aging, including reduced albuminuria, decreased inflammation, and apoptosis in the vascular endothelium, increased aortic elasticity, greater motor coordination, reduced cataract formation, and preserved bone mineral density. However, mice fed a standard diet did not live longer when treated with resveratrol beginning at 12 months of age. Our findings indicate that resveratrol treatment has a range of beneficial effects in mice but does not increase the longevity of ad libitum-fed animals when started midlife.
Description: 22 páginas, 4 figuras.
Publisher version (URL): http://dx.doi.org/10.1016/j.cmet.2008.06.011
URI: http://hdl.handle.net/10261/41582
ISSN: 1550-4131
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Citation: Cell Metabolism 8(2): 157-168 (2008)
References: PMC2538685
PMID: 18599363
NIHMS57083
Appears in Collections:(CABD) Artículos
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