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Título: | Hydroxylation of demethoxy-Q6 constitutes a control point in yeast coenzyme Q6 biosynthesis |
Autor: | Padilla, Sergio; Tran, U. C.; Jiménez-Hidalgo, María CSIC; López-Martín, José María; Martín-Montalvo, Alejandro CSIC ORCID; Clarke, Catherine F.; Navas, Plácido CSIC ORCID; Santos-Ocaña, Carlos CSIC ORCID | Palabras clave: | Ubiquinone Coenzyme Q10 Mitochondria Yeast regulation |
Fecha de publicación: | 11-nov-2008 | Editor: | Birkhäuser Verlag | Citación: | Cellular and Molecular Life Sciences 66(1): 173-186 (2009) | Resumen: | Coenzyme Q is a lipid molecule required for respiration and antioxidant protection. Q biosynthesis in Saccharomyces cerevisiae requires nine proteins (Coq1p–Coq9p). We demonstrate in this study that Q levels are modulated during growth by its conversion from demethoxy-Q (DMQ), a late intermediate. Similar conversion was produced when cells were subjected to oxidative stress conditions. Changes in Q6/DMQ6 ratio were accompanied by changes in COQ7 gene mRNA levels encoding the protein responsible for the DMQ hydroxylation, the penultimate step in Q biosynthesis pathway. Yeast coq null mutant failed to accumulate any Q late biosynthetic intermediate. However, in coq7 mutants the addition of exogenous Q produces the DMQ synthesis. Similar effect was produced by over-expressing ABC1/COQ8. These results support the existence of a biosynthetic complex that allows the DMQ6 accumulation and suggest that Coq7p is a control point for the Q biosynthesis regulation in yeast. | Descripción: | 23 páginas, 8 figuras, 2 tablas. | Versión del editor: | http://dx.doi.org/10.1007/s00018-008-8547-7 | URI: | http://hdl.handle.net/10261/41492 | DOI: | 10.1007/s00018-008-8547-7 | ISSN: | 1420-682X | E-ISSN: | 1420-9071 |
Aparece en las colecciones: | (CABD) Artículos |
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