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dc.contributor.authorCastelli-Gair Hombría, James-
dc.contributor.authorSotillos, Sol-
dc.date.accessioned2011-10-19T13:09:53Z-
dc.date.available2011-10-19T13:09:53Z-
dc.date.issued2008-06-11-
dc.identifier.citationSeminars in Cell and Developmental Biology 19(4): 370-378 (2008)es_ES
dc.identifier.issn1084-9521-
dc.identifier.otherPMID: 18590829-
dc.identifier.urihttp://hdl.handle.net/10261/41421-
dc.description9 páginas, 3 figuras, 1 tabla.es_ES
dc.description.abstractThe components of many signalling pathways are localised in specific cellular compartments in polarised cells. This is particularly clear in the case of the receptors that localise to the apical or basal membrane in the epithelial cells. In many cases this subcellular localisation is important for the activation of the signalling pathways. In this review we analyse recent developments uncovering an interesting interplay between JAK/STAT signalling and components regulating cell polarity and adhesion during development. Not only the JAK/STAT signalling components are polarised in epithelial cells but many genes controlling cell polarity and adhesion are targets of STAT and in some cases these components act as pathway activators. The fact that in most morphogenetic processes cell adhesion and polarity proteins are regulated downstream of the pathway, hints at a possible unifying mechanistic explanation for the diverse morphogenetic processes controlled by JAK/STAT during development.es_ES
dc.description.sponsorshipThis work was supported by the Spanish Ministerio de Educación y Ciencia, FEDER and Junta de Andalucía. S.S. is a Ramón y Cajal Fellow.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.subjectJAK/STATes_ES
dc.subjectSignallinges_ES
dc.subjectCell polarityes_ES
dc.subjectCell adhesiones_ES
dc.subjectDevelopmentes_ES
dc.titleDisclosing JAK/STAT links to cell adhesion and cell polarityes_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.semcdb.2008.06.002-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.semcdb.2008.06.002es_ES
dc.identifier.e-issn1096-3634-
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