English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/41396
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:


The RNA binding protein Zfp36l1 is required for normal vascularisation and post-transcriptionally regulates VEGF expression

AuthorsBell, Sarah E.; Sánchez, María José ; Spasic-Boskovic, Olivera; Santalucía, Tomàs ; Gambardella, Laure; Burton, Graham J.; Murphy, John J.; Norton, John D.; Clark, Andrew R.; Turner, Martin
Extraembryonic and intraembryonic vasculature
Nuclear proteins
Vascular Endothelial Growth Factor A
Issue Date29-Sep-2006
CitationDevelopmental Dynamics 235(11): 3144-3155 (2006)
AbstractThe Zfp36l1 gene encodes a zinc finger-containing mRNA binding protein implicated in the posttranscriptional control of gene expression. Mouse embryos homozygous for a targeted mutation in the Zfp36l1 locus died mid-gestation and exhibited extraembryonic and intraembryonic vascular abnormalities and heart defects. In the developing placenta, there was a failure of the extraembryonic mesoderm to invaginate the trophoblast layer. The phenotype was associated with an elevated expression of vascular endothelial growth factor (VEGF)-A in the embryos and in embryonic fibroblasts cultured under conditions of both normoxia and hypoxia. VEGF-A overproduction by embryonic fibroblasts was not a consequence of changes in Vegf-a mRNA stability; instead, we observed enhanced association with polyribosomes, suggesting Zfp36l1 influences translational regulation. These data implicate Zfp36l1as a negative regulator of Vegf-a gene activity during development.
Description12 páginas, 9 figuras, 1 tabla.
Publisher version (URL)http://dx.doi.org/10.1002/dvdy.20949
Appears in Collections:(CABD) Artículos
Files in This Item:
There are no files associated with this item.
Show full item record
Review this work

Related articles:

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.