DSpace

Digital.CSIC > Biología y Biomedicina > Centro Andaluz de Biología del Desarrollo (CABD) > (CABD) Artículos >

Share

EndNote

Impact

Links

Closed Access item JAK/STAT signalling in Drosophila controls cell motility during germ cell migration

Authors:Brown, Stephen
Zeidler, Martin P.
Castelli-Gair Hombría, James
Keywords:JAK/STAT, Pole cells, Drosophila, Primordial germ cells, Gonad, Migration, Cell survival, Filopodia
Issue Date:13-Feb-2006
Publisher:Wiley-Liss
Citation:Developmental Dynamics 235(4): 958-966 (2006)
Abstract:The gonad is formed from two populations of cells originating at different locations: the primordial germ cells (PGCs), giving rise to either sperm or oocytes, and the somatic gonadal mesoderm precursors (SGPs), which support development of the gametes. Following the PGCs' migration during gastrulation, these two populations meet, forming the immature gonad. We present evidence that during embryonic development, the PGCs require the canonical JAK/STAT signalling cascade to migrate efficiently towards the SGPs. Loss of function for any element of the JAK/STAT pathway causes frequent germ cell mislocalisation. We have found that wild-type germ cells produce filopodia while they migrate through the mesoderm towards the gonad. Our observations suggest that PGCs use filopodia to migrate and to keep contact with each other. Interestingly, activation of the JAK/STAT pathway is required for these filopodia to form, and ectopic JAK/STAT activation enhances their formation.
Description:9 páginas, 6 figuras.
Publisher version (URL):http://dx.doi.org/10.1002/dvdy.20709
URI:http://hdl.handle.net/10261/41389
ISSN:1058-8388
E-ISSNmetadata.dc.identifier.doi = DOI:1097-0177
???metadata.dc.identifier.doi???:10.1002/dvdy.20709
Appears in Collections:(CABD) Artículos

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.