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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/41389
Title: JAK/STAT signalling in Drosophila controls cell motility during germ cell migration
Authors: Brown, Stephen; Zeidler, Martin P.; Castelli-Gair Hombría, James
Keywords: JAK/STAT
Pole cells
Primordial germ cells
Cell survival
Issue Date: 13-Feb-2006
Publisher: Wiley-Liss
Citation: Developmental Dynamics 235(4): 958-966 (2006)
Abstract: The gonad is formed from two populations of cells originating at different locations: the primordial germ cells (PGCs), giving rise to either sperm or oocytes, and the somatic gonadal mesoderm precursors (SGPs), which support development of the gametes. Following the PGCs' migration during gastrulation, these two populations meet, forming the immature gonad. We present evidence that during embryonic development, the PGCs require the canonical JAK/STAT signalling cascade to migrate efficiently towards the SGPs. Loss of function for any element of the JAK/STAT pathway causes frequent germ cell mislocalisation. We have found that wild-type germ cells produce filopodia while they migrate through the mesoderm towards the gonad. Our observations suggest that PGCs use filopodia to migrate and to keep contact with each other. Interestingly, activation of the JAK/STAT pathway is required for these filopodia to form, and ectopic JAK/STAT activation enhances their formation.
Description: 9 páginas, 6 figuras.
Publisher version (URL): http://dx.doi.org/10.1002/dvdy.20709
URI: http://hdl.handle.net/10261/41389
DOI: 10.1002/dvdy.20709
ISSN: 1058-8388
E-ISSN: 1097-0177
References: PMID: 16477645
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