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Título

New technologies, new findings, and new concepts in the study of vertebrate cis-regulatory sequences

AutorGómez-Skarmeta, José Luis CSIC ORCID ; Lenhard, Boris; Becker, Thomas S.
Palabras claveEnhacer detection
Phylogenetic footprinting
Synteny
Gene deserts
Mouse
Human genome
Highly conserved noncoding regions
Hox cluster
Fecha de publicación4-ene-2006
EditorWiley-Liss
CitaciónDevelopmental Dynamics 235(4): 870-885 (2006)
ResumenAll vertebrates share a similar early embryonic body plan and use the same regulatory genes for their development. The availability of numerous sequenced vertebrate genomes and significant advances in bioinformatics have resulted in the finding that the genomic regions of many of these developmental regulatory genes also contain highly conserved noncoding sequence. In silico discovery of conserved noncoding regions and of transcription factor binding sites as well as the development of methods for high throughput transgenesis in Xenopus and zebrafish are dramatically increasing the speed with which regulatory elements can be discovered, characterized, and tested in the context of whole live embryos. We review here some of the recent technological developments that will likely lead to a surge in research on how vertebrate genomes encode regulation of transcriptional activity, how regulatory sequences constrain genomic architecture, and ultimately how vertebrate form has evolved.
Descripción16 páginas, 7 figuras.
Versión del editorhttp://dx.doi.org/10.1002/dvdy.20659
URIhttp://hdl.handle.net/10261/41387
DOI10.1002/dvdy.20659
ISSN1058-8388
E-ISSN1097-0177
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