Por favor, use este identificador para citar o enlazar a este item:
http://hdl.handle.net/10261/41198
COMPARTIR / EXPORTAR:
SHARE CORE BASE | |
Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL | DATACITE | |
Título: | Organ-injury-induced reactivation of hemangioblastic precursor cells |
Autor: | Dekel, Benjamin; Metsuyanim, S.; García, A. M.; Quintero, C.; Sánchez, María José CSIC ORCID CVN; Izraeli, Shai | Palabras clave: | Antigens Basic Helix-Loop-Helix Transcription Factors Endothelium Flow cytometry Hematopoietic stem cells Pregnancy Proto-oncogene proteins Vascular endothelial growth factor receptor |
Fecha de publicación: | 1-ene-2008 | Editor: | Nature Publishing Group | Citación: | Leukemia 22(1): 103-113 (2008) | Resumen: | Early in mammalian development, the stem cell leukemia (SCL/TAL1) gene and its distinct 3' enhancer (SCL 3'En) specify bipotential progenitor cells that give rise to blood and endothelium, thus termed hemangioblasts. We have previously detected a minor population of SCL (+) cells in the postnatal kidney. Here, we demonstrate that cells expressing the SCL 3'En in the adult kidney are comprised of CD45+CD31- hematopoietic cells, CD45-CD31+ endothelial cells and CD45-CD31- interstitial cells. Creation of bone marrow chimeras of SCL 3'En transgenic mice into wild-type hosts shows that all three types of SCL 3'En-expressing cells in the adult kidney can originate from the bone marrow. Ischemia/reperfusion injury to the adult kidney of SCL 3'En transgenic mice results in the intrarenal elevation of SCL and FLK1 mRNA levels and of cells expressing hem-endothelial progenitor markers (CD45, CD34, c-Kit and FLK1). Furthermore, analysis of SCL 3'En in the ischemic kidneys reveals an increase in the abundance of SCL 3'En-expressing cells, predominantly within the CD45 (+) hematopoietic fraction and to a lesser extent in the CD45 (-) fraction. Our results suggest organ-injury-induced reactivation of bone marrow-derived hemangioblasts and possible local angioblastic progenitors expressing SCL and SCL 3'En. | Descripción: | 11 páginas. | Versión del editor: | http://dx.doi.org/10.1038/sj.leu.2404941 | URI: | http://hdl.handle.net/10261/41198 | DOI: | 10.1038/sj.leu.2404941 | ISSN: | 0887-6924 | E-ISSN: | 1476-5551 |
Aparece en las colecciones: | (CABD) Artículos |
Mostrar el registro completo
CORE Recommender
SCOPUSTM
Citations
11
checked on 13-abr-2024
WEB OF SCIENCETM
Citations
10
checked on 28-feb-2024
Page view(s)
314
checked on 23-abr-2024
Google ScholarTM
Check
Altmetric
Altmetric
NOTA: Los ítems de Digital.CSIC están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.