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Organ-injury-induced reactivation of hemangioblastic precursor cells

AuthorsDekel, Benjamin; Metsuyanim, S.; García, A. M. ; Quintero, C.; Sánchez, María José ; Izraeli, Shai
Basic Helix-Loop-Helix Transcription Factors
Flow cytometry
Hematopoietic stem cells
Proto-oncogene proteins
Vascular endothelial growth factor receptor
Issue Date1-Jan-2008
PublisherNature Publishing Group
CitationLeukemia 22(1): 103-113 (2008)
AbstractEarly in mammalian development, the stem cell leukemia (SCL/TAL1) gene and its distinct 3' enhancer (SCL 3'En) specify bipotential progenitor cells that give rise to blood and endothelium, thus termed hemangioblasts. We have previously detected a minor population of SCL (+) cells in the postnatal kidney. Here, we demonstrate that cells expressing the SCL 3'En in the adult kidney are comprised of CD45+CD31- hematopoietic cells, CD45-CD31+ endothelial cells and CD45-CD31- interstitial cells. Creation of bone marrow chimeras of SCL 3'En transgenic mice into wild-type hosts shows that all three types of SCL 3'En-expressing cells in the adult kidney can originate from the bone marrow. Ischemia/reperfusion injury to the adult kidney of SCL 3'En transgenic mice results in the intrarenal elevation of SCL and FLK1 mRNA levels and of cells expressing hem-endothelial progenitor markers (CD45, CD34, c-Kit and FLK1). Furthermore, analysis of SCL 3'En in the ischemic kidneys reveals an increase in the abundance of SCL 3'En-expressing cells, predominantly within the CD45 (+) hematopoietic fraction and to a lesser extent in the CD45 (-) fraction. Our results suggest organ-injury-induced reactivation of bone marrow-derived hemangioblasts and possible local angioblastic progenitors expressing SCL and SCL 3'En.
Description11 páginas.
Publisher version (URL)http://dx.doi.org/10.1038/sj.leu.2404941
Appears in Collections:(CABD) Artículos
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