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Closed Access item Amitriptyline induces coenzyme Q deficiency and oxidative damage in mouse lung and liver

Authors:Bautista-Ferrufino, María Rosa
Cordero, Mario D.
Sánchez-Alcázar, José Antonio
Illanes, Matilde
Fernández-Rodríguez, Ana
Navas, Plácido
Miguel, Manuel de
Keywords:Amitriptyline, Coenzyme Q, Lipid peroxidation, Oxidative stress, Antidepressive agents, Ubiquinone
Issue Date:9-Apr-2011
Citation:Toxicology Letters 204(1): 32-37 (2011)
Abstract:Amitriptyline is a tricyclic antidepressant commonly prescribed for the treatment of several neuropathic and inflammatory illnesses. We have already reported that amitriptyline has cytotoxic effect in human cell cultures, increasing oxidative stress, and decreasing growth rate and mitochondrial activity. Coenzyme Q (CoQ), a component of the respiratory chain and a potent antioxidant, has been proposed as a mitochondrial dysfunction marker. In the present work we evaluated lipid peroxidation, a consequence of oxidative stress, and CoQ level in liver, lung, kidney, brain, heart, skeletal muscle, and serum of mice treated with amitriptyline for two weeks. Lipid peroxidation was increased in a dose-dependent manner in all tissues analyzed. CoQ levels were increased in brain, heart, skeletal muscle, and serum, and strongly decreased in liver and lung. The relation between amitriptyline, CoQ, and oxidative stress is discussed.
Description:6 páginas, 4 figuras.
Publisher version (URL):http://dx.doi.org/10.1016/j.toxlet.2011.03.033
Appears in Collections:(CABD) Artículos

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