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Closed Access item Estrogen modulates norepinephrine-induced accumulation of adenosine cyclic monophosphate in a subpopulation of immortalized luteinizing hormone-releasing hormone secreting neurons from the mouse hypothalamus

Authors:Martínez-Morales, Juan Ramón
Morales, A.
Marín, R.
Hernández-Jiménez, J. G.
Acevedo, A.
Guerra, B.
Hernández, G.
López-Coviella, I.
Prieto, L.
Alonso, R.
Keywords:Estrogen, Norepinephrine, Cyclic adenosine monophosphate, GT1-7 cells, Luteinizing hormone-releasing hormone, Estrogen receptor
Issue Date:5-Jan-2001
Publisher:Elsevier
Citation:Neuroscience Letters 298(1): 61-64 (2001)
Abstract:A subpopulation of luteinizing hormone-releasing hormone (LHRH)-producing cells that express the intermediate filament protein vimentin and the neuronal marker neurofilament 145, but not neurofilament 200 nor glial fibrillary acidic protein, has been isolated from GT1–7 cultures. These cells express the mRNA encoding estrogen receptor alpha (ERα) and respond to physiological concentrations of 17β-estradiol (E2) by reducing the accumulation of cyclic adenosine monophosphate induced by norepinephrine, but not that induced by direct activation of adenylate cyclase. These results indicate that the activity of LHRH-producing neurons may be directly modulated by estrogen. In addition, they are suggestive of an estrogen-dependent desensitization of the β-adrenoceptor in these cells.
Description:4 páginas, 3 figuras, 1 tabla.
Publisher version (URL):http://dx.doi.org/10.1016/S0304-3940(00)01722-5
URI:http://hdl.handle.net/10261/41083
ISSN:0304-3940
E-ISSNmetadata.dc.identifier.doi = DOI:1872-7972
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Appears in Collections:(CABD) Artículos

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