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Título : Estrogen modulates norepinephrine-induced accumulation of adenosine cyclic monophosphate in a subpopulation of immortalized luteinizing hormone-releasing hormone secreting neurons from the mouse hypothalamus
Autor : Martínez-Morales, Juan Ramón, Morales, A., Marín, R., Hernández-Jiménez, J. G., Acevedo, A., Guerra, B., Hernández, G., López-Coviella, I., Prieto, L., Alonso, Rafael
Palabras clave : Estrogen
Cyclic adenosine monophosphate
GT1-7 cells
Luteinizing hormone-releasing hormone
Estrogen receptor
Fecha de publicación : 5-Jan-2001
Editor: Elsevier
Resumen: A subpopulation of luteinizing hormone-releasing hormone (LHRH)-producing cells that express the intermediate filament protein vimentin and the neuronal marker neurofilament 145, but not neurofilament 200 nor glial fibrillary acidic protein, has been isolated from GT1–7 cultures. These cells express the mRNA encoding estrogen receptor alpha (ERα) and respond to physiological concentrations of 17β-estradiol (E2) by reducing the accumulation of cyclic adenosine monophosphate induced by norepinephrine, but not that induced by direct activation of adenylate cyclase. These results indicate that the activity of LHRH-producing neurons may be directly modulated by estrogen. In addition, they are suggestive of an estrogen-dependent desensitization of the β-adrenoceptor in these cells.
Descripción : 4 páginas, 3 figuras, 1 tabla.
Versión del editor:
ISSN: 0304-3940
DOI: 10.1016/S0304-3940(00)01722-5
Citación : Neuroscience Letters 298(1): 61-64 (2001)
Referencias: PMID: 11154836
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