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SMC proteins, new players in the maintenance of genomic stability

AuthorsCortés-Ledesma, Felipe ; Piccoli, Giaccomo de; Haber, James E.; Aragón, Luis; Aguilera, Andrés
KeywordsSister chromatid exchange
Double-strand break repair
Homologous Recombination
Break-induced replication
Collapsed replication forks
MRX/MRN complex
SMC complexes
Issue Date15-Apr-2007
PublisherLandes Bioscience
CitationCell Cycle 6(8): 914-918 (2007)
AbstractHomologous recombination (HR) is one of the key mechanisms responsible for the repair of DNA double-strand breaks (DSBs), including those that occur during DNA replication. Recent studies in yeast and mammals have uncovered that the SMC complexes cohesins and Smc5-Smc6 are recruited to induced DSBs, and play a role in the maintenance of genome stability by favouring SCR as the main recombinational DSB repair mechanism. These new results raise intriguing questions such as whether SMC proteins might play a functional role at collapsed replication forks, which may represent the main source of spontaneous recombinogenic damage. A deeper knowledge of the role of SMC proteins in DSB repair should contribute to a better understanding of chromosome dynamics and stability.
DescriptionPMID: 17404505.-- Previously published online as a Cell Cycle E-publication: http://www.landesbioscience.com/journals/cc/abstract.php?id=4107
Publisher version (URL)http://dx.doi.org/10.4161/cc.6.8.4107
Appears in Collections:(CABIMER) Artículos
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