Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/40781
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Title: Coenzyme Q supports distinct developmental processes in Caenorhabditis elegans
Authors: Asencio, Claudio, Navas, Plácido, Cabello, Juan, Schnabel, Ralf, Cysper, James R., Johnson, Thomas E., Rodríguez-Aguilera, Juan Carlos
Keywords: Development
Fertility
Ubiquinone
Antioxidant
Elegans
Caenorhabditis elegans
Coenzyme Q10
Phenotype
Issue Date: 1-Sep-2008
Publisher: Elsevier
Abstract: Coenzyme Q (Q) regulates aging in Caenorhabditis elegans, and its deficiency leads to a variety of pathologies in humans. We used a coq-8 deleted strain to study the role of Q in C. elegans development and how it influences life span. Endogenous Q9 content of coq-8(ok840) knockouts was demonstrated to be about 7% of that found in the wild-type, indicating the basal biosynthesis rate is reduced in this strain. Knockouts abnormally developed both gonads and hypodermis, showed reduced fertility and shortened life span, and this was partially recovered by ingestion of exogenous Q. Knockouts produced embryos that showed arrested development at the time of initial expression of coq-8 in embryo. Uridine, whose biosynthesis depends on mitochondrial Q, improved both egg production and progeny under Q-rich dietary conditions. COQ-8 is a candidate protein for post-translational regulation of Q biosynthesis rate and its expression correlates with Q content during the life cycle in C. elegans. We show for the first time that a critical level of Q is necessary to support embryo development and fertility in C. elegans. These results suggest that extra-mitochondrial function of Q is a key factor linking development and bioenergetics in C. elegans.
Description: 9 páginas, 8 figuras.
Publisher version (URL): http://dx.doi.org/10.1016/j.mad.2008.10.004
URI: http://hdl.handle.net/10261/40781
ISSN: 0047-6374
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Citation: Mechanisms of Ageing and Development 130(3): 145-153 (2009)
References: PMID: 19007804
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