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dc.contributor.authorArroyo, Antonio-
dc.contributor.authorSantos-Ocaña, Carlos-
dc.contributor.authorRuiz-Ferrer, Macarena-
dc.contributor.authorPadilla, Sergio-
dc.contributor.authorGavilán, Angela-
dc.contributor.authorRodríguez-Aguilera, Juan Carlos-
dc.contributor.authorNavas, Plácido-
dc.date.accessioned2011-10-06T09:30:26Z-
dc.date.available2011-10-06T09:30:26Z-
dc.date.issued2006-02-20-
dc.identifier.citationFEBS Letters 580(7): 1740-1746 (2006)es_ES
dc.identifier.issn0014-5793-
dc.identifier.otherPMID: 16504181-
dc.identifier.urihttp://hdl.handle.net/10261/40674-
dc.description7 páginas, 5 figuras, 2 tablas.es_ES
dc.description.abstractA procedure was developed to isolate fractions enriched in plasma membrane from Caenorhabditis elegans. Coenzyme Q9 (Q9) was found in plasma membrane isolated from either wild-type or long-lived qm30 and qm51 clk-1 mutant strains of Caenorhabditis elegans, along with dietary coenzyme Q8 (Q8) and the biosynthetic intermediate demethoxy-Q9 (DMQ9). NADH was able to reduce both Q8 and Q9, but not DMQ9. Our results indicate that DMQ9 cannot achieve the same redox role of Q9 in plasma membrane, suggesting that proportion of all these Q isoforms in plasma membrane must be an important factor in establishing the clk-1 mutant phenotype.es_ES
dc.description.sponsorshipThis work has been supported by the Spanish Ministerio de Ciencia y Tecnología, Grant BFU2005-03017/BMC. A.A. was supported by the Junta de Andalucía “Programa de Incorporación de Doctores a Centros de Investigación Andaluces”. A.G. was supported by The 6th Framework Programme – STREP/LSHB-CT-2004-005151.es_ES
dc.language.isoenges_ES
dc.publisherFederation of European Biochemical Societieses_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.subjectCoenzyme Q10es_ES
dc.subjectDemethoxy-coenzyme Qes_ES
dc.subjectPlasma membranees_ES
dc.subjectclk-1 mutant phenotypees_ES
dc.subjectCaenorhabditis eleganses_ES
dc.subjectUbiquinonees_ES
dc.titleCoenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane of Caenorhabditis eleganses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.febslet.2006.02.025-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.febslet.2006.02.025es_ES
dc.identifier.e-issn1873-3468-
dc.type.coarhttp://purl.org/coar/resource_type/c_6501es_ES
item.openairetypeartículo-
item.grantfulltextnone-
item.cerifentitytypePublications-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextNo Fulltext-
item.languageiso639-1en-
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