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Closed Access item Coenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane of Caenorhabditis elegans

Authors:Arroyo, Antonio
Santos-Ocaña, Carlos
Ruiz-Ferrer, Macarena
Padilla, Sergio
Gavilán, Ángela
Rodríguez-Aguilera, Juan Carlos
Navas, Plácido
Keywords:Coenzyme Q10, Demethoxy-coenzyme Q, Plasma membrane, clk-1 mutant phenotype, Caenorhabditis elegans, Ubiquinone
Issue Date:20-Feb-2006
Publisher:Federation of European Biochemical Societies
Citation:FEBS Letters 580(7): 1740-1746 (2006)
Abstract:A procedure was developed to isolate fractions enriched in plasma membrane from Caenorhabditis elegans. Coenzyme Q9 (Q9) was found in plasma membrane isolated from either wild-type or long-lived qm30 and qm51 clk-1 mutant strains of Caenorhabditis elegans, along with dietary coenzyme Q8 (Q8) and the biosynthetic intermediate demethoxy-Q9 (DMQ9). NADH was able to reduce both Q8 and Q9, but not DMQ9. Our results indicate that DMQ9 cannot achieve the same redox role of Q9 in plasma membrane, suggesting that proportion of all these Q isoforms in plasma membrane must be an important factor in establishing the clk-1 mutant phenotype.
Description:7 páginas, 5 figuras, 2 tablas.
Publisher version (URL):http://dx.doi.org/10.1016/j.febslet.2006.02.025
E-ISSNmetadata.dc.identifier.doi = DOI:1873-3468
Appears in Collections:(CABD) Artículos

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