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Coenzyme Q is irreplaceable by demethoxy-coenzyme Q in plasma membrane of Caenorhabditis elegans

AuthorsArroyo, Antonio ; Santos-Ocaña, Carlos ; Ruiz-Ferrer, Macarena; Padilla, Sergio; Gavilán, Angela; Rodríguez-Aguilera, Juan Carlos ; Navas, Plácido
KeywordsCoenzyme Q10
Demethoxy-coenzyme Q
Plasma membrane
clk-1 mutant phenotype
Caenorhabditis elegans
Issue Date20-Feb-2006
PublisherFederation of European Biochemical Societies
CitationFEBS Letters 580(7): 1740-1746 (2006)
AbstractA procedure was developed to isolate fractions enriched in plasma membrane from Caenorhabditis elegans. Coenzyme Q9 (Q9) was found in plasma membrane isolated from either wild-type or long-lived qm30 and qm51 clk-1 mutant strains of Caenorhabditis elegans, along with dietary coenzyme Q8 (Q8) and the biosynthetic intermediate demethoxy-Q9 (DMQ9). NADH was able to reduce both Q8 and Q9, but not DMQ9. Our results indicate that DMQ9 cannot achieve the same redox role of Q9 in plasma membrane, suggesting that proportion of all these Q isoforms in plasma membrane must be an important factor in establishing the clk-1 mutant phenotype.
Description7 páginas, 5 figuras, 2 tablas.
Publisher version (URL)http://dx.doi.org/10.1016/j.febslet.2006.02.025
Appears in Collections:(CABD) Artículos
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