Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/40659
Share/Impact:
Título : The Xenopus Irx genes are essential for neural patterning and define the border between prethalamus and thalamus through mutual antagonism with the anterior repressors Fezf and Arx
Autor : Rodríguez-Seguel, Elisa, Alarcón, Pilar, Gómez-Skarmeta, José Luis
Palabras clave : Iroquois
Fez
Arx
Neural develpment
Xenopus
Morpholio
Fecha de publicación : 4-Mar-2009
Editor: Elsevier
Citación : Developmental Biology - Kidlington 329(2): 258-268(2009)
Resumen: The Iroquois (Irx) genes encode homeoproteins conserved during evolution. Vertebrate genomes contain six Irx genes organized in two clusters, IrxA (which harbors Irx1, Irx2 and Irx4) and IrxB (which harbors Irx3, Irx5 and Irx6). To determine the precise role of these genes during development and their putative redundancies, we conducted a comparative expression analysis and a comprehensive loss-of-function study of all the early expressed Irx genes (Irx1–5) using specific morpholinos in Xenopus. We found that the five Irx genes display largely overlapping expression patterns and contribute to neural patterning. All Irx genes are required for proper formation of posterior forebrain, midbrain, hindbrain and, to a lesser an extent, spinal cord. Nevertheless, Irx1 and Irx3 seem to have a predominant role during regionalization of the neural plate. In addition, we find that the common anterior limit of Irx gene expression, which will correspond to the future border between the prethalamus and thalamus, is defined by mutual repression between Fezf and Irx proteins. This mutual repression is likely direct. Finally, we show that Arx, another anteriorly expressed repressor, also contribute to delineate the anterior border of Irx expression.
Descripción : 11 páginas, 8 figuras.
Versión del editor: http://dx.doi.org/10.1016/j.ydbio.2009.02.028
URI : http://hdl.handle.net/10261/40659
ISSN: 0012-1606
DOI: 10.1016/j.ydbio.2009.02.028
Appears in Collections:(CABD) Artículos

Files in This Item:
There are no files associated with this item.
Show full item record
 
CSIC SFX LinksSFX Query


Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.