English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/40655
Share/Impact:
Statistics
logo share SHARE logo core CORE   Add this article to your Mendeley library MendeleyBASE

Visualizar otros formatos: MARC | Dublin Core | RDF | ORE | MODS | METS | DIDL
Exportar a otros formatos:

DC FieldValueLanguage
dc.contributor.authorCordero, Mario D.-
dc.contributor.authorMoreno-Fernández, Ana M.-
dc.contributor.authorCarmona-López, María I.-
dc.contributor.authorSánchez-Alcázar, José Antonio-
dc.contributor.authorFernández-Rodríguez, Ana-
dc.contributor.authorNavas, Plácido-
dc.contributor.authorMiguel, Manuel de-
dc.date.accessioned2011-10-06T07:01:51Z-
dc.date.available2011-10-06T07:01:51Z-
dc.date.issued2010-07-01-
dc.identifier.citationClinical Biochemistry 43(13-14): 1174-1176 (2010)es_ES
dc.identifier.issn0009-9120-
dc.identifier.otherPMID: 20599870-
dc.identifier.urihttp://hdl.handle.net/10261/40655-
dc.description3 páginas, 1 figura, 1 tabla.es_ES
dc.description.abstract[Objectives]: Coenzyme Q10 (CoQ10) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Signs associated with skin alteration and mitochondrial dysfunction have been observed in patients with fibromyalgia (FM). The aim of this study was to analyze CoQ10 levels, mitochondrial dysfunction, and oxidative stress in plasma, blood mononuclear cells, and skin biopsies from FM patients. [Methods]: We studied CoQ10 level by HPLC in plasma, blood mononuclear cells, and skin obtained from patients with FM and healthy control subjects. Oxidative stress markers and mitochondrial respiratory chain enzyme activities were analysed in both plasma, blood mononuclear cells, and skin biopsies from FM patients. [Results]: Oxidative stress, mitochondrial dysfunction, and CoQ10 deficiency have been observed in blood mononuclear cells and skin biopsies. [Conclusions]: In our patients, mitochondrial dysfunction and CoQ10 deficiency are present in several tissues. These results may contribute to the understanding of the pathophysiology of FM, and, moreover, CoQ10 deficiency could represent a good marker for the diagnosis of FM.es_ES
dc.language.isoenges_ES
dc.publisherElsevieres_ES
dc.rightsclosedAccesses_ES
dc.subjectFibromyalgiaes_ES
dc.subjectBlood mononuclear cellses_ES
dc.subjectSkines_ES
dc.subjectCoenzyme Q10es_ES
dc.subjectOxidative stresses_ES
dc.subjectMitochondrial dysfunctiones_ES
dc.subjectUbiquinonees_ES
dc.subjectLeukocyteses_ES
dc.titleMitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patientses_ES
dc.typeartículoes_ES
dc.identifier.doi10.1016/j.clinbiochem.2010.06.013-
dc.description.peerreviewedPeer reviewedes_ES
dc.relation.publisherversionhttp://dx.doi.org/10.1016/j.clinbiochem.2010.06.013es_ES
Appears in Collections:(CABD) Artículos
Files in This Item:
File Description SizeFormat 
accesoRestringido.pdf15,38 kBAdobe PDFThumbnail
View/Open
Show simple item record
 

Related articles:


WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.