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Closed Access item Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients

Authors:Cordero, Mario D.
Moreno-Fernández, Ana M.
Carmona-López, María Inés
Sánchez-Alcázar, José Antonio
Fernández Rodríguez, Ana
Navas, Plácido
Miguel, Manuel de
Keywords:Fibromyalgia, Blood mononuclear cells, Skin, Coenzyme Q10, Oxidative stress, Mitochondrial dysfunction, Ubiquinone, Leukocytes
Issue Date:1-Jul-2010
Canadian Society of Clinical Chemists
Citation:Clinical Biochemistry - New York 43(13-14): 1174-1176 (2010)
Abstract:Objectives: Coenzyme Q10 (CoQ10) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Signs associated with skin alteration and mitochondrial dysfunction have been observed in patients with fibromyalgia (FM). The aim of this study was to analyze CoQ10 levels, mitochondrial dysfunction, and oxidative stress in plasma, blood mononuclear cells, and skin biopsies from FM patients. Methods: We studied CoQ10 level by HPLC in plasma, blood mononuclear cells, and skin obtained from patients with FM and healthy control subjects. Oxidative stress markers and mitochondrial respiratory chain enzyme activities were analysed in both plasma, blood mononuclear cells, and skin biopsies from FM patients. Results: Oxidative stress, mitochondrial dysfunction, and CoQ10 deficiency have been observed in blood mononuclear cells and skin biopsies. Conclusions: In our patients, mitochondrial dysfunction and CoQ10 deficiency are present in several tissues. These results may contribute to the understanding of the pathophysiology of FM, and, moreover, CoQ10 deficiency could represent a good marker for the diagnosis of FM.
Description:3 páginas, 1 figura, 1 tabla.
Publisher version (URL):http://dx.doi.org/10.1016/j.clinbiochem.2010.06.013
Appears in Collections:(CABD) Artículos

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