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Title

Mitochondrial dysfunction in skin biopsies and blood mononuclear cells from two cases of fibromyalgia patients

AuthorsCordero, Mario D. ; Moreno-Fernández, Ana M.; Carmona-López, María I.; Sánchez-Alcázar, José Antonio ; Fernández-Rodríguez, Ana; Navas, Plácido ; Miguel, Manuel de
KeywordsFibromyalgia
Blood mononuclear cells
Skin
Coenzyme Q10
Oxidative stress
Mitochondrial dysfunction
Ubiquinone
Leukocytes
Issue Date1-Jul-2010
PublisherElsevier
CitationClinical Biochemistry 43(13-14): 1174-1176 (2010)
Abstract[Objectives]: Coenzyme Q10 (CoQ10) is an essential electron carrier in the mitochondrial respiratory chain and a strong antioxidant. Signs associated with skin alteration and mitochondrial dysfunction have been observed in patients with fibromyalgia (FM). The aim of this study was to analyze CoQ10 levels, mitochondrial dysfunction, and oxidative stress in plasma, blood mononuclear cells, and skin biopsies from FM patients. [Methods]: We studied CoQ10 level by HPLC in plasma, blood mononuclear cells, and skin obtained from patients with FM and healthy control subjects. Oxidative stress markers and mitochondrial respiratory chain enzyme activities were analysed in both plasma, blood mononuclear cells, and skin biopsies from FM patients. [Results]: Oxidative stress, mitochondrial dysfunction, and CoQ10 deficiency have been observed in blood mononuclear cells and skin biopsies. [Conclusions]: In our patients, mitochondrial dysfunction and CoQ10 deficiency are present in several tissues. These results may contribute to the understanding of the pathophysiology of FM, and, moreover, CoQ10 deficiency could represent a good marker for the diagnosis of FM.
Description3 páginas, 1 figura, 1 tabla.
Publisher version (URL)http://dx.doi.org/10.1016/j.clinbiochem.2010.06.013
URIhttp://hdl.handle.net/10261/40655
DOI10.1016/j.clinbiochem.2010.06.013
ISSN0009-9120
Appears in Collections:(CABD) Artículos
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