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Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/40650
Title: Analysis of Coenzyme Q10 in muscle and fibroblasts for the diagnosis of CoQ10 deficiency syndromes
Authors: Montero, Raquel; Sánchez-Alcázar, José Antonio; Briones, Paz; Rodríguez-Hernández, Ángeles; Cordero, Mario D.; Trevisson, Eva; Salviati, Leonardo; Pineda, Mercé; García-Cazorla, Angels; Navas, Plácido; Artuch, Rafael
Keywords: Biological markers
Electron Transport
Coenzyme Q10
Issue Date: 20-Mar-2008
Publisher: Elsevier
Canadian Society of Clinical Chemists
Citation: Clinical Biochemistry - New York 41(9): 697-700 (2008)
Abstract: OBJECTIVES: To study CoQ(10) concentrations in muscle and fibroblast from 6 patients with a CoQ(10) deficiency syndrome. DESIGN AND METHODS: CoQ(10) was quantified by HPLC with electrochemical detection. RESULTS: Four out of the 6 cases showed muscle CoQ(10) deficiency plus a reduction of mitochondrial respiratory chain enzyme activities. All cases showed decreased CoQ(10) values in fibroblasts when compared with controls. CONCLUSIONS: Biochemical study of CoQ(10) in both muscle and fibroblasts seems advisable to demonstrate the deficiency in all patients.
Description: 4 páginas, 2 tablas.
Publisher version (URL): http://dx.doi.org/10.1016/j.clinbiochem.2008.03.007
URI: http://hdl.handle.net/10261/40650
ISSN: 0009-9120
DOI: 10.1016/j.clinbiochem.2008.03.007
References: PMID: 18387363
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