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Título : Analysis of Coenzyme Q10 in muscle and fibroblasts for the diagnosis of CoQ10 deficiency syndromes
Autor : Montero, Raquel, Sánchez-Alcázar, José Antonio, Briones, Paz, Rodríguez-Hernández, Ángeles, Cordero, Mario D., Trevisson, Eva, Salviati, Leonardo, Pineda, Mercé, García-Cazorla, Angels, Navas, Plácido, Artuch, Rafael
Palabras clave : Biological markers
Electron Transport
Coenzyme Q10
Fecha de publicación : 20-Mar-2008
Editor: Elsevier
Canadian Society of Clinical Chemists
Resumen: OBJECTIVES: To study CoQ(10) concentrations in muscle and fibroblast from 6 patients with a CoQ(10) deficiency syndrome. DESIGN AND METHODS: CoQ(10) was quantified by HPLC with electrochemical detection. RESULTS: Four out of the 6 cases showed muscle CoQ(10) deficiency plus a reduction of mitochondrial respiratory chain enzyme activities. All cases showed decreased CoQ(10) values in fibroblasts when compared with controls. CONCLUSIONS: Biochemical study of CoQ(10) in both muscle and fibroblasts seems advisable to demonstrate the deficiency in all patients.
Descripción : 4 páginas, 2 tablas.
Versión del editor:
ISSN: 0009-9120
DOI: 10.1016/j.clinbiochem.2008.03.007
Citación : Clinical Biochemistry - New York 41(9): 697-700 (2008)
Referencias: PMID: 18387363
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