English   español  
Please use this identifier to cite or link to this item: http://hdl.handle.net/10261/40620
Title: Study of the potential association of adipose tissue GLP-1 receptor with obesity and insulin resistance
Authors: Vendrell, Joan; El Bekay, Rajaa; Peral, Belén ; Garcia-Fuentes, Eduardo; Macías-González, Manuel; Fernández-Real, José M.; Escoté, Xavier; Simó, Rafael; Tinahones, Francisco J.
Keywords: Glucagon-like peptide 1
Type 2 diabetes mellytus
Issue Date: 23-Aug-2012
Publisher: Endocrine Society
Citation: Endocrinology 152(11): 4072-4079 (2011)
Abstract: The increase in glucagon-like peptide-1 (GLP-1) activity has emerged as a useful therapeutic tool for the treatment of type 2 diabetes mellitus. The actions of GLP-1 on β-cells and the nervous and digestive systems are well known. The action of this peptide in adipose tissue (AT), however, is still poorly defined. Furthermore, no relationship has been established between GLP-1 receptor (GLP-1R) in AT and obesity and insulin resistance (IR). We provide evidence for the presence of this receptor in AT and show that its mRNA and protein expressions are increased in visceral adipose depots from morbidly obese patients with a high degree of IR. Experiments with the 3T3-L1 cell line showed the lipolytic and lipogenic dose-dependent effect of GLP-1. Moreover, GLP-1 stimulated lipolysis in 3T3-L1 adipocytes in a receptor-dependent manner involving downstream adenylate cyclase/cAMP signaling. Our data also demonstrate that the expression of the GLP-1R in AT correlated positively with the homeostasis model assessment index in obese IR subjects. Furthermore, prospective studies carried out with patients that underwent biliopancreatic diversion surgery showed that subjects with high levels of GLP-1R expression in AT, which indicates a deficit of GLP-1 in this tissue, were those whose insulin sensitivity improved after surgery, suggesting the potential relationship between AT GLP-1R and insulin sensitivity amelioration in obese subjects. Altogether these results indicate that the GLP-1/GLP-1R system in AT represents another potential candidate for improving insulin sensitivity in obese patients.
Description: 8 páginas, 5 figuras.-- et al.
Publisher version (URL): http://doi.dx.org/10.1210/en.2011-1070
URI: http://hdl.handle.net/10261/40620
DOI: 10.1210/en.2011-1070
ISSN: 0013-7227
E-ISSN: 1945-7170
Appears in Collections:(IIBM) Artículos
Files in This Item:
File Description SizeFormat 
Study of the Potential.pdf270,57 kBAdobe PDFThumbnail
Show full item record

WARNING: Items in Digital.CSIC are protected by copyright, with all rights reserved, unless otherwise indicated.