DSpace

Digital.CSIC > Biología y Biomedicina > Instituto de Investigaciones Biomédicas "Alberto Sols" (IIBM) > (IIBM) Artículos >

Share

EndNote

Impact

Open Access item Decreased STAMP2 expression in association with visceral adipose tissue dysfunction

Authors:Moreno-Navarrete, José M.
Ortega, Francisco J.
Pérez-Pérez, Rafael
Ricart, Wifredo
Peral, Belén
Fernández-Real, José M.
Keywords:STAMP2, Human obesity, Gene expression, Type 2 diabetes
Issue Date:17-Aug-2011
Publisher:Endocrine Society
Citation:Journal of Clinical Endocrinology and Metabolism 96(11): E1816-E1825 (2011)
Abstract:[Context]: Six-transmembrane protein of prostate 2 (STAMP2) is a counter-regulator of inflammation and insulin resistance according to findings in mice. However, there have been contradictory reports in humans. [Objective]: We aimed to explore STAMP2 in association with inflammatory and metabolic status of human obesity. [Design, Patients, and Methods]: STAMP2 gene expression was analyzed in adipose tissue samples (171 visceral and 67 sc depots) and during human preadipocyte differentiation. Human adipocytes were treated with macrophage-conditioned medium, TNF-α, and rosiglitazone. [Results]: In visceral adipose tissue, STAMP2 gene expression was significantly decreased in obese subjects, mainly in obese subjects with type 2 diabetes. STAMP2 gene expression and protein were significantly and inversely associated with obesity phenotype measures (body mass index, waist, hip, and fat mass) and obesity-associated metabolic disturbances (systolic blood pressure and fasting glucose). In addition, STAMP2 gene expression was positively associated with lipogenic (FASN, ACC1, SREBP1, THRSP14, TRα, and TRα1), CAV1, IRS1, GLUT4, and CD206 gene expression. In sc adipose tissue, STAMP2 gene expression was not associated with metabolic parameters. In both fat depots, STAMP2 gene expression in stromovascular cells was significantly higher than in mature adipocytes. STAMP2 gene expression was significantly increased during the differentiation process in parallel to adipogenic genes, being increased in preadipocytes derived from lean subjects. Macrophage-conditioned medium (25%) and TNF-α (100 ng/ml) administration increased whereas rosiglitazone (2 μM) decreased significantly STAMP2 gene expression in human differentiated adipocytes. [Conclusions]: Decreased STAMP2 expression (mRNA and protein) might reflect visceral adipose dysfunction in subjects with obesity and type 2 diabetes.
Description:10 páginas, 6 figuras, 2 tablas.-- et al.
Publisher version (URL):http://dx.doi.org/10.1210/jc.2011-0310
URI:http://hdl.handle.net/10261/40602
ISSN:0021-972X
E-ISSNmetadata.dc.identifier.doi = DOI:1945-7197
???metadata.dc.identifier.doi???:10.1210/jc.2011-0310
Appears in Collections:(IIBM) Artículos

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.