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Title: | NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast |
Authors: | Jiménez-Hidalgo, María CSIC; Santos-Ocaña, Carlos CSIC ORCID ; Padilla, Sergio; Villalba, José M.; López-Lluch, Guillermo CSIC ORCID CVN ; Martín-Montalvo, Alejandro CSIC ORCID; Minor, Robin K.; Sinclair, David A.; Cabo, Rafael de; Navas, Plácido CSIC ORCID | Keywords: | Chronological lifespan Coenzyme Q Coencyme Q reductase Dietary restriction NQR1 Plasma membrane Replicative lifespan Cell aging Electron transport complex Energy metabolism Ethanol Histone deacetylases Saccharomyces cerevisiae Sirtuins |
Issue Date: | 23-Feb-2009 | Publisher: | Blackwell Publishing | Citation: | Aging Cell 8(2): 140-151 (2009) | Abstract: | The activity and expression of plasma membrane NADH coenzyme Q reductase is increased by calorie restriction (CR) in rodents. Although this effect is well-established and is necessary for CR's ability to delay aging, the mechanism is unknown. Here we show that the Saccharomyces cerevisiae homolog, NADH-Coenzyme Q reductase 1 (NQR1), resides at the plasma membrane and when overexpressed extends both replicative and chronological lifespan. We show that NQR1 extends replicative lifespan in a SIR2-dependent manner by shifting cells towards respiratory metabolism. Chronological lifespan extension, in contrast, occurs via an SIR2-independent decrease in ethanol production. We conclude that NQR1 is a key mediator of lifespan extension by CR through its effects on yeast metabolism and discuss how these findings could suggest a function for this protein in lifespan extension in mammals. | Description: | 22 páginas, 8 figuras. | Publisher version (URL): | http://dx.doi.org/10.1111/j.1474-9726.2009.00461.x | URI: | http://hdl.handle.net/10261/40151 | DOI: | 10.1111/j.1474-9726.2009.00461.x | ISSN: | 1474-9718 | E-ISSN: | 1474-9726 |
Appears in Collections: | (CABD) Artículos |
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