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Open Access item NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast

Authors:Jiménez-Hidalgo, María
Santos-Ocaña, Carlos
Padilla, Sergio
Villalba, José M.
López-Lluch, Guillermo
Martín-Montalvo, Alejandro
Minor, Robin K.
Sinclair, David A.
Cabo, Rafael de
Navas, Plácido
Keywords:Chronological lifespan, Coenzyme Q, Coencyme Q reductase, Dietary restriction, NQR1, Plasma membrane, Replicative lifespan, Cell aging, Electron transport complex, Energy metabolism, Ethanol, Histone Deacetylases, Saccharomyces cerevisiae, Sirtuins
Issue Date:23-Feb-2009
Publisher:Blackwell Publishing
Citation:Aging Cell 8(2): 140-151 (2009)
Abstract:The activity and expression of plasma membrane NADH coenzyme Q reductase is increased by calorie restriction (CR) in rodents. Although this effect is well-established and is necessary for CR's ability to delay aging, the mechanism is unknown. Here we show that the Saccharomyces cerevisiae homolog, NADH-Coenzyme Q reductase 1 (NQR1), resides at the plasma membrane and when overexpressed extends both replicative and chronological lifespan. We show that NQR1 extends replicative lifespan in a SIR2-dependent manner by shifting cells towards respiratory metabolism. Chronological lifespan extension, in contrast, occurs via an SIR2-independent decrease in ethanol production. We conclude that NQR1 is a key mediator of lifespan extension by CR through its effects on yeast metabolism and discuss how these findings could suggest a function for this protein in lifespan extension in mammals.
Description:22 páginas, 8 figuras.
Publisher version (URL):http://dx.doi.org/10.1111/j.1474-9726.2009.00461.x
E-ISSNmetadata.dc.identifier.doi = DOI:1474-9726
Appears in Collections:(CABD) Artículos

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