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Título : NQR1 controls lifespan by regulating the promotion of respiratory metabolism in yeast
Autor : Jiménez-Hidalgo, María, Santos-Ocaña, Carlos, Padilla, Sergio, Villalba, José M., López-Lluch, Guillermo, Martín-Montalvo, Alejandro, Minor, Robin K., Sinclair, David A., Cabo, Rafael de, Navas, Plácido
Palabras clave : Chronological lifespan
Coenzyme Q
Coencyme Q reductase
Dietary restriction
Plasma membrane
Replicative lifespan
Cell aging
Electron transport complex
Energy metabolism
Histone Deacetylases
Saccharomyces cerevisiae
Fecha de publicación : 23-Feb-2009
Editor: Blackwell Publishing
Resumen: The activity and expression of plasma membrane NADH coenzyme Q reductase is increased by calorie restriction (CR) in rodents. Although this effect is well-established and is necessary for CR's ability to delay aging, the mechanism is unknown. Here we show that the Saccharomyces cerevisiae homolog, NADH-Coenzyme Q reductase 1 (NQR1), resides at the plasma membrane and when overexpressed extends both replicative and chronological lifespan. We show that NQR1 extends replicative lifespan in a SIR2-dependent manner by shifting cells towards respiratory metabolism. Chronological lifespan extension, in contrast, occurs via an SIR2-independent decrease in ethanol production. We conclude that NQR1 is a key mediator of lifespan extension by CR through its effects on yeast metabolism and discuss how these findings could suggest a function for this protein in lifespan extension in mammals.
Descripción : 22 páginas, 8 figuras.
Versión del editor:
ISSN: 1474-9718
DOI: 10.1111/j.1474-9726.2009.00461.x
Citación : Aging Cell 8(2): 140-151 (2009)
Referencias: PMC2699585
PMID: 19239415
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